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Chronic NMDA administration to rats increases brain pro-apoptotic factors while decreasing anti-Apoptotic factors and causes cell death

BACKGROUND: Chronic N-Methyl-d-aspartate (NMDA) administration to rats is reported to increase arachidonic acid signaling and upregulate neuroinflammatory markers in rat brain. These changes may damage brain cells. In this study, we determined if chronic NMDA administration (25 mg/kg i.p., 21 days)...

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Detalles Bibliográficos
Autores principales:	Kim, Hyung-Wook, Chang, Yunyoung C, Chen, Mei, Rapoport, Stanley I, Rao, Jagadeesh S
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762981/ https://www.ncbi.nlm.nih.gov/pubmed/19785755 http://dx.doi.org/10.1186/1471-2202-10-123

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