Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives

S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homose...

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Detalles Bibliográficos
Autores principales: Sufrin, Janice R., Finckbeiner, Steven, Oliver, Colin M.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763108/
https://www.ncbi.nlm.nih.gov/pubmed/19841722
http://dx.doi.org/10.3390/md7030401
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author Sufrin, Janice R.
Finckbeiner, Steven
Oliver, Colin M.
author_facet Sufrin, Janice R.
Finckbeiner, Steven
Oliver, Colin M.
author_sort Sufrin, Janice R.
collection PubMed
description S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homoserine lactones. Marine organisms produce numerous AdoMet metabolites whose novel structures can be regarded as lead compounds for anti-infective drug design.
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spelling pubmed-27631082009-10-19 Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives Sufrin, Janice R. Finckbeiner, Steven Oliver, Colin M. Mar Drugs Review S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homoserine lactones. Marine organisms produce numerous AdoMet metabolites whose novel structures can be regarded as lead compounds for anti-infective drug design. Molecular Diversity Preservation International 2009-08-26 /pmc/articles/PMC2763108/ /pubmed/19841722 http://dx.doi.org/10.3390/md7030401 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Sufrin, Janice R.
Finckbeiner, Steven
Oliver, Colin M.
Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives
title Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives
title_full Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives
title_fullStr Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives
title_full_unstemmed Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives
title_short Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives
title_sort marine-derived metabolites of s-adenosylmethionine as templates for new anti-infectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763108/
https://www.ncbi.nlm.nih.gov/pubmed/19841722
http://dx.doi.org/10.3390/md7030401
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