Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens

Two new jaspamide derivatives 2 and 3, together with the parent compound jaspamide (1) have been isolated from the marine sponge Jaspis splendens collected in Kalimantan (Indonesia). The structures of the new compounds were unambiguously elucidated based on 1D and 2D NMR spectral data, mass spectrom...

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Detalles Bibliográficos
Autores principales: Ebada, Sherif S., Wray, Victor, de Voogd, Nicole J., Deng, Zhiwei, Lin, Wenhan, Proksch, Peter
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763109/
https://www.ncbi.nlm.nih.gov/pubmed/19841723
http://dx.doi.org/10.3390/md7030435
Descripción
Sumario:Two new jaspamide derivatives 2 and 3, together with the parent compound jaspamide (1) have been isolated from the marine sponge Jaspis splendens collected in Kalimantan (Indonesia). The structures of the new compounds were unambiguously elucidated based on 1D and 2D NMR spectral data, mass spectrometry and comparison with jaspamide (1). The new derivatives inhibited the growth of mouse lymphoma (L5178Y) cell line in vitro with IC(50) values of <0.1 μg/mL.

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