Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens

Two new jaspamide derivatives 2 and 3, together with the parent compound jaspamide (1) have been isolated from the marine sponge Jaspis splendens collected in Kalimantan (Indonesia). The structures of the new compounds were unambiguously elucidated based on 1D and 2D NMR spectral data, mass spectrom...

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Detalles Bibliográficos
Autores principales: Ebada, Sherif S., Wray, Victor, de Voogd, Nicole J., Deng, Zhiwei, Lin, Wenhan, Proksch, Peter
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763109/
https://www.ncbi.nlm.nih.gov/pubmed/19841723
http://dx.doi.org/10.3390/md7030435
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author Ebada, Sherif S.
Wray, Victor
de Voogd, Nicole J.
Deng, Zhiwei
Lin, Wenhan
Proksch, Peter
author_facet Ebada, Sherif S.
Wray, Victor
de Voogd, Nicole J.
Deng, Zhiwei
Lin, Wenhan
Proksch, Peter
author_sort Ebada, Sherif S.
collection PubMed
description Two new jaspamide derivatives 2 and 3, together with the parent compound jaspamide (1) have been isolated from the marine sponge Jaspis splendens collected in Kalimantan (Indonesia). The structures of the new compounds were unambiguously elucidated based on 1D and 2D NMR spectral data, mass spectrometry and comparison with jaspamide (1). The new derivatives inhibited the growth of mouse lymphoma (L5178Y) cell line in vitro with IC(50) values of <0.1 μg/mL.
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spelling pubmed-27631092009-10-19 Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens Ebada, Sherif S. Wray, Victor de Voogd, Nicole J. Deng, Zhiwei Lin, Wenhan Proksch, Peter Mar Drugs Article Two new jaspamide derivatives 2 and 3, together with the parent compound jaspamide (1) have been isolated from the marine sponge Jaspis splendens collected in Kalimantan (Indonesia). The structures of the new compounds were unambiguously elucidated based on 1D and 2D NMR spectral data, mass spectrometry and comparison with jaspamide (1). The new derivatives inhibited the growth of mouse lymphoma (L5178Y) cell line in vitro with IC(50) values of <0.1 μg/mL. Molecular Diversity Preservation International 2009-09-15 /pmc/articles/PMC2763109/ /pubmed/19841723 http://dx.doi.org/10.3390/md7030435 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ebada, Sherif S.
Wray, Victor
de Voogd, Nicole J.
Deng, Zhiwei
Lin, Wenhan
Proksch, Peter
Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens
title Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens
title_full Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens
title_fullStr Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens
title_full_unstemmed Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens
title_short Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens
title_sort two new jaspamide derivatives from the marine sponge jaspis splendens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763109/
https://www.ncbi.nlm.nih.gov/pubmed/19841723
http://dx.doi.org/10.3390/md7030435
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