1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp

A new cyclic diamine, 1,5-diazacyclohenicosane (1), was isolated from samples of the marine sponge Mycale sp. collected at Lamu Island (Kenya). Its structure was determined by a combination of spectroscopic techniques, including (+)-HRESIMS and 1D and 2D NMR spectroscopy. The compound displayed cyto...

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Detalles Bibliográficos
Autores principales: Coello, Laura, Martín, María Jesús, Reyes, Fernando
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763110/
https://www.ncbi.nlm.nih.gov/pubmed/19841724
http://dx.doi.org/10.3390/md7030445
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author Coello, Laura
Martín, María Jesús
Reyes, Fernando
author_facet Coello, Laura
Martín, María Jesús
Reyes, Fernando
author_sort Coello, Laura
collection PubMed
description A new cyclic diamine, 1,5-diazacyclohenicosane (1), was isolated from samples of the marine sponge Mycale sp. collected at Lamu Island (Kenya). Its structure was determined by a combination of spectroscopic techniques, including (+)-HRESIMS and 1D and 2D NMR spectroscopy. The compound displayed cytotoxicity at the μM level against three human tumor cell lines.
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spelling pubmed-27631102009-10-19 1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp Coello, Laura Martín, María Jesús Reyes, Fernando Mar Drugs Article A new cyclic diamine, 1,5-diazacyclohenicosane (1), was isolated from samples of the marine sponge Mycale sp. collected at Lamu Island (Kenya). Its structure was determined by a combination of spectroscopic techniques, including (+)-HRESIMS and 1D and 2D NMR spectroscopy. The compound displayed cytotoxicity at the μM level against three human tumor cell lines. Molecular Diversity Preservation International 2009-09-15 /pmc/articles/PMC2763110/ /pubmed/19841724 http://dx.doi.org/10.3390/md7030445 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Coello, Laura
Martín, María Jesús
Reyes, Fernando
1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp
title 1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp
title_full 1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp
title_fullStr 1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp
title_full_unstemmed 1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp
title_short 1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp
title_sort 1,5-diazacyclohenicosane, a new cytotoxic metabolite from the marine sponge mycale sp
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763110/
https://www.ncbi.nlm.nih.gov/pubmed/19841724
http://dx.doi.org/10.3390/md7030445
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AT reyesfernando 15diazacyclohenicosaneanewcytotoxicmetabolitefromthemarinespongemycalesp

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