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Lipid peroxidation and antioxidant status in head and neck squamous cell carcinoma patients

Oxidative stress, a consequence of an imbalance between the formation and inactivation of reactive oxygen species, may be involved in the pathogenesis of many diseases including cancer. To evaluate the magnitude of oxidative stress, a study on the plasma levels of superoxide dismutase, total thiols,...

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Detalles Bibliográficos
Autores principales: Gupta, Aashita, Bhatt, Madan L B, Misra, Mithilesh K
Formato: Texto
Lenguaje:English
Publicado: Landes Bioscience 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763247/
https://www.ncbi.nlm.nih.gov/pubmed/20357927
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author Gupta, Aashita
Bhatt, Madan L B
Misra, Mithilesh K
author_facet Gupta, Aashita
Bhatt, Madan L B
Misra, Mithilesh K
author_sort Gupta, Aashita
collection PubMed
description Oxidative stress, a consequence of an imbalance between the formation and inactivation of reactive oxygen species, may be involved in the pathogenesis of many diseases including cancer. To evaluate the magnitude of oxidative stress, a study on the plasma levels of superoxide dismutase, total thiols, ascorbic acid and malondialdehyde (MDA) has been done in head and neck squamous cell carcinoma patients before the start of any oncological treatment and compared with healthy controls. The specific activity of superoxide dismutase in cancer patients is decreased significantly when compared to the control (p < 0.05). The total thiol and ascorbic acid levels are significantly reduced (p < 0.005) whereas MDA levels are significantly increased in the patients (p < 0.00005). Our findings show that the oxidative stress is elevated in cancer patients as evidenced by elevated levels of lipid peroxidation products and depletion of enzymatic and non-enzymatic antioxidants.
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spelling pubmed-27632472010-04-01 Lipid peroxidation and antioxidant status in head and neck squamous cell carcinoma patients Gupta, Aashita Bhatt, Madan L B Misra, Mithilesh K Oxid Med Cell Longev Research Papers Oxidative stress, a consequence of an imbalance between the formation and inactivation of reactive oxygen species, may be involved in the pathogenesis of many diseases including cancer. To evaluate the magnitude of oxidative stress, a study on the plasma levels of superoxide dismutase, total thiols, ascorbic acid and malondialdehyde (MDA) has been done in head and neck squamous cell carcinoma patients before the start of any oncological treatment and compared with healthy controls. The specific activity of superoxide dismutase in cancer patients is decreased significantly when compared to the control (p < 0.05). The total thiol and ascorbic acid levels are significantly reduced (p < 0.005) whereas MDA levels are significantly increased in the patients (p < 0.00005). Our findings show that the oxidative stress is elevated in cancer patients as evidenced by elevated levels of lipid peroxidation products and depletion of enzymatic and non-enzymatic antioxidants. Landes Bioscience 2009 /pmc/articles/PMC2763247/ /pubmed/20357927 Text en Copyright © 2009 Landes Bioscience
spellingShingle Research Papers
Gupta, Aashita
Bhatt, Madan L B
Misra, Mithilesh K
Lipid peroxidation and antioxidant status in head and neck squamous cell carcinoma patients
title Lipid peroxidation and antioxidant status in head and neck squamous cell carcinoma patients
title_full Lipid peroxidation and antioxidant status in head and neck squamous cell carcinoma patients
title_fullStr Lipid peroxidation and antioxidant status in head and neck squamous cell carcinoma patients
title_full_unstemmed Lipid peroxidation and antioxidant status in head and neck squamous cell carcinoma patients
title_short Lipid peroxidation and antioxidant status in head and neck squamous cell carcinoma patients
title_sort lipid peroxidation and antioxidant status in head and neck squamous cell carcinoma patients
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763247/
https://www.ncbi.nlm.nih.gov/pubmed/20357927
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