High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors

A critical feature of Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), is its ability to survive and multiply within macrophages, making these host cells an ideal niche for persisting microbes. Killing the intracellular tubercle bacilli is a key requirement for efficient t...

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Detalles Bibliográficos
Autores principales: Christophe, Thierry, Jackson, Mary, Jeon, Hee Kyoung, Fenistein, Denis, Contreras-Dominguez, Monica, Kim, Jaeseung, Genovesio, Auguste, Carralot, Jean-Philippe, Ewann, Fanny, Kim, Eun Hye, Lee, Sae Yeon, Kang, Sunhee, Seo, Min Jung, Park, Eun Jung, Škovierová, Henrieta, Pham, Ha, Riccardi, Giovanna, Nam, Ji Youn, Marsollier, Laurent, Kempf, Marie, Joly-Guillou, Marie-Laure, Oh, Taegwon, Shin, Won Kyung, No, Zaesung, Nehrbass, Ulf, Brosch, Roland, Cole, Stewart T., Brodin, Priscille
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763345/
https://www.ncbi.nlm.nih.gov/pubmed/19876393
http://dx.doi.org/10.1371/journal.ppat.1000645

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