Regulation of HIF-1α and VEGF by miR-20b Tunes Tumor Cells to Adapt to the Alteration of Oxygen Concentration

The regulation of HIF-1α is considered to be realized by pVHL-mediated ubiquitin-26S proteasome pathway at a post-transcriptional level. The discovery of a class of small noncoding RNAs, called microRNAs, implies alternative mechanism of regulation of HIF-1α. Here, we show that miR-20b plays an impo...

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Detalles Bibliográficos
Autores principales: Lei, Zhang, Li, Bo, Yang, Zhuoshun, Fang, Haoshu, Zhang, Gui-Mei, Feng, Zuo-Hua, Huang, Bo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764090/
https://www.ncbi.nlm.nih.gov/pubmed/19893619
http://dx.doi.org/10.1371/journal.pone.0007629

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