Loss of Hepatocyte-Nuclear-Factor-4α Affects Colonic Ion Transport and Causes Chronic Inflammation Resembling Inflammatory Bowel Disease in Mice

BACKGROUND: Hnf4α, an epithelial specific transcriptional regulator, is decreased in inflammatory bowel disease and protects against chemically-induced colitis in mice. However, the precise role of this factor in maintaining normal inflammatory homeostasis of the intestine remains unclear. The aim o...

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Detalles Bibliográficos
Autores principales: Darsigny, Mathieu, Babeu, Jean-Philippe, Dupuis, Andrée-Anne, Furth, Emma E., Seidman, Ernest G., Lévy, Émile, Verdu, Elena F., Gendron, Fernand-Pierre, Boudreau, François
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764139/
https://www.ncbi.nlm.nih.gov/pubmed/19898610
http://dx.doi.org/10.1371/journal.pone.0007609

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