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Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase
Mammalian polynucleotide kinase (mPNK) is a critical DNA repair enzyme whose 5′-kinase and 3′-phoshatase activities function with poorly understood but striking specificity to restore 5′-phosphate/3′-hydroxyl termini at sites of DNA damage. Here we integrated site-directed mutagenesis and small-angl...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764422/ https://www.ncbi.nlm.nih.gov/pubmed/19671525 http://dx.doi.org/10.1093/nar/gkp597 |