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Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe
BACKGROUND: Primary hepatocellular carcinoma (PHC) is one of the most common cancers in Zimbabwe. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are suspected to play a major role in causing this cancer. The objective of this study was to determine the seroprevalence of HBV and HCV in PHC at Pa...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764566/ https://www.ncbi.nlm.nih.gov/pubmed/19814789 http://dx.doi.org/10.1186/1750-9378-4-15 |
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author | Chin'ombe, Nyasha Chavhunduka, Evans Matarira, Hilda T |
author_facet | Chin'ombe, Nyasha Chavhunduka, Evans Matarira, Hilda T |
author_sort | Chin'ombe, Nyasha |
collection | PubMed |
description | BACKGROUND: Primary hepatocellular carcinoma (PHC) is one of the most common cancers in Zimbabwe. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are suspected to play a major role in causing this cancer. The objective of this study was to determine the seroprevalence of HBV and HCV in PHC at Parirenyatwa Referral Hospital in Zimbabwe. We evaluated the serological markers of the two viruses in patients with PHC using commercially available enzyme-linked immunosorbent kits. RESULTS: Out of the 60 patients with PHC, 48.3% were seropositive for HBV and 20.0% were seropositive for HCV. Co-infection by HCV and HBV was found in 8% of the patients. Only 13.3% of the health controls (blood donors) were positive for HBV. All the controls were negative for HCV. CONCLUSION: The high seropositivity of HBV and HCV in PHC in Zimbabwe suggested that the two viruses were a major cause of the cancer. |
format | Text |
id | pubmed-2764566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27645662009-10-21 Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe Chin'ombe, Nyasha Chavhunduka, Evans Matarira, Hilda T Infect Agent Cancer Research Article BACKGROUND: Primary hepatocellular carcinoma (PHC) is one of the most common cancers in Zimbabwe. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are suspected to play a major role in causing this cancer. The objective of this study was to determine the seroprevalence of HBV and HCV in PHC at Parirenyatwa Referral Hospital in Zimbabwe. We evaluated the serological markers of the two viruses in patients with PHC using commercially available enzyme-linked immunosorbent kits. RESULTS: Out of the 60 patients with PHC, 48.3% were seropositive for HBV and 20.0% were seropositive for HCV. Co-infection by HCV and HBV was found in 8% of the patients. Only 13.3% of the health controls (blood donors) were positive for HBV. All the controls were negative for HCV. CONCLUSION: The high seropositivity of HBV and HCV in PHC in Zimbabwe suggested that the two viruses were a major cause of the cancer. BioMed Central 2009-10-08 /pmc/articles/PMC2764566/ /pubmed/19814789 http://dx.doi.org/10.1186/1750-9378-4-15 Text en Copyright © 2009 Chin'ombe et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Chin'ombe, Nyasha Chavhunduka, Evans Matarira, Hilda T Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe |
title | Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe |
title_full | Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe |
title_fullStr | Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe |
title_full_unstemmed | Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe |
title_short | Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe |
title_sort | seroprevalence of hbv and hcv in primary hepatocellular carcinoma patients in zimbabwe |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764566/ https://www.ncbi.nlm.nih.gov/pubmed/19814789 http://dx.doi.org/10.1186/1750-9378-4-15 |
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