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PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells

BACKGROUND: Airway smooth muscle contributes to the pathogenesis of pulmonary diseases by secreting inflammatory mediators such as interleukin-8 (IL-8). IL-8 production is in part regulated via activation of G(q)-and G(s)-coupled receptors. Here we study the role of the cyclic AMP (cAMP) effectors p...

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Detalles Bibliográficos
Autores principales:	Roscioni, Sara S, Kistemaker, Loes EM, Menzen, Mark H, Elzinga, Carolina RS, Gosens, Reinoud, Halayko, Andrew J, Meurs, Herman, Schmidt, Martina
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764632/ https://www.ncbi.nlm.nih.gov/pubmed/19788733 http://dx.doi.org/10.1186/1465-9921-10-88

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