Differential protection by wildtype vs. organelle-specific Bcl-2 suggests a combined requirement of both the ER and mitochondria in ceramide-mediated caspase-independent programmed cell death

BACKGROUND: Programmed cell death (PCD) is essential for development and homeostasis of multicellular organisms and can occur by caspase-dependent apoptosis or alternatively, by caspase-independent PCD (ciPCD). Bcl-2, a central regulator of apoptosis, localizes to both mitochondria and the endoplasm...

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Detalles Bibliográficos
Autores principales: Deerberg, Andrea, Sosna, Justyna, Thon, Lutz, Belka, Claus, Adam, Dieter
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764721/
https://www.ncbi.nlm.nih.gov/pubmed/19818125
http://dx.doi.org/10.1186/1748-717X-4-41

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