Toward a Molecular Understanding of the Interaction of Dual Specificity Phosphatases with Substrates: Insights from Structure-Based Modeling and High Throughput Screening

Dual-specificity phosphatases (DSPs) are important, but poorly understood, cell signaling enzymes that remove phosphate groups from tyrosine and serine/threonine residues on their substrate. Deregulation of DSPs has been implicated in cancer, obesity, diabetes, inflammation, and Alzheimer’s disease....

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Detalles Bibliográficos
Autores principales: Bakan, Ahmet, Lazo, John S, Wipf, Peter, Brummond, Kay M, Bahar, Ivet
Formato: Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764859/
https://www.ncbi.nlm.nih.gov/pubmed/18855677
http://dx.doi.org/10.2174/092986708785909003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764859/
https://www.ncbi.nlm.nih.gov/pubmed/18855677
http://dx.doi.org/10.2174/092986708785909003

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