Towards Retinoid Therapy for Alzheimer’s Disease

Alzheimer’s disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and age-related changes. Retinoic acid receptors (RARs) and retinoids are relevant to...

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Detalles Bibliográficos
Autores principales: Shudo, K, Fukasawa, H, Nakagomi, M, Yamagata, N
Formato: Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd. 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765081/
https://www.ncbi.nlm.nih.gov/pubmed/19519313
http://dx.doi.org/10.2174/156720509788486581
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author Shudo, K
Fukasawa, H
Nakagomi, M
Yamagata, N
author_facet Shudo, K
Fukasawa, H
Nakagomi, M
Yamagata, N
author_sort Shudo, K
collection PubMed
description Alzheimer’s disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and age-related changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD.
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spelling pubmed-27650812009-10-23 Towards Retinoid Therapy for Alzheimer’s Disease Shudo, K Fukasawa, H Nakagomi, M Yamagata, N Curr Alzheimer Res Article Alzheimer’s disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and age-related changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD. Bentham Science Publishers Ltd. 2009-06 /pmc/articles/PMC2765081/ /pubmed/19519313 http://dx.doi.org/10.2174/156720509788486581 Text en ©2009 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/) which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Shudo, K
Fukasawa, H
Nakagomi, M
Yamagata, N
Towards Retinoid Therapy for Alzheimer’s Disease
title Towards Retinoid Therapy for Alzheimer’s Disease
title_full Towards Retinoid Therapy for Alzheimer’s Disease
title_fullStr Towards Retinoid Therapy for Alzheimer’s Disease
title_full_unstemmed Towards Retinoid Therapy for Alzheimer’s Disease
title_short Towards Retinoid Therapy for Alzheimer’s Disease
title_sort towards retinoid therapy for alzheimer’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765081/
https://www.ncbi.nlm.nih.gov/pubmed/19519313
http://dx.doi.org/10.2174/156720509788486581
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