Influence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domains

Reverse transcriptases from HIV-1 and MuLV respectively prefer Mg(2+ )and Mn(2+ )for their polymerase activity, with variable fidelity, on both RNA and DNA templates. The function of the RNase H domain with respect to these parameters is not yet understood. To evaluate this function, two chimeric en...

Descripción completa

Detalles Bibliográficos
Autores principales: Talele, Tanaji T, Upadhyay, Alok, Pandey, Virendra N
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765437/
https://www.ncbi.nlm.nih.gov/pubmed/19814799
http://dx.doi.org/10.1186/1743-422X-6-159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765437/
https://www.ncbi.nlm.nih.gov/pubmed/19814799
http://dx.doi.org/10.1186/1743-422X-6-159

Ejemplares similares