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Influence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domains
Reverse transcriptases from HIV-1 and MuLV respectively prefer Mg(2+ )and Mn(2+ )for their polymerase activity, with variable fidelity, on both RNA and DNA templates. The function of the RNase H domain with respect to these parameters is not yet understood. To evaluate this function, two chimeric en...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765437/ https://www.ncbi.nlm.nih.gov/pubmed/19814799 http://dx.doi.org/10.1186/1743-422X-6-159 |