Identification of Potent Chemotypes Targeting Leishmania major Using a High-Throughput, Low-Stringency, Computationally Enhanced, Small Molecule Screen

Patients with clinical manifestations of leishmaniasis, including cutaneous leishmaniasis, have limited treatment options, and existing therapies frequently have significant untoward liabilities. Rapid expansion in the diversity of available cutaneous leishmanicidal chemotypes is the initial step in...

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Detalles Bibliográficos
Autores principales: Sharlow, Elizabeth R., Close, David, Shun, Tongying, Leimgruber, Stephanie, Reed, Robyn, Mustata, Gabriela, Wipf, Peter, Johnson, Jacob, O'Neil, Michael, Grögl, Max, Magill, Alan J., Lazo, John S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765639/
https://www.ncbi.nlm.nih.gov/pubmed/19888337
http://dx.doi.org/10.1371/journal.pntd.0000540

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