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Effect of structural modification at the 4, 3′, and 2′ positions of doxorubicin on topoisomerase II poisoning, apoptosis, and cytotoxicity in human melanoma cells

INTRODUCTION: The mechanism of the cytotoxicity of anthracyclines is pleiotropic and its significance in cell growth inhibition seems to be highly specific and dependent on cell type and anthracycline drug. Resistance and the high cardiotoxicity of anthracyclines have stimulated many studies aimed a...

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Detalles Bibliográficos
Autores principales:	Gruber, Beata M., Anuszewska, Elżbieta L., Bubko, Irena, Goździk, Aneta, Fokt, Izabela, Priebe, Waldemar
Formato:	Texto
Lenguaje:	English
Publicado:	Birkhäuser-Verlag 2007
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765644/ https://www.ncbi.nlm.nih.gov/pubmed/17557149 http://dx.doi.org/10.1007/s00005-007-0018-6

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