Severe atovaquone-resistant Plasmodium falciparum malaria in a Canadian traveller returned from the Indian subcontinent

BACKGROUND: We report the first case of atovaquone/proguanil treatment failure in severe Plasmodium falciparum malaria acquired by a non-immune traveller to the Indian subcontinent. Recrudescent infection was complicated by neurological involvement 14 days after directly observed therapy with atovaq...

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Detalles Bibliográficos
Autores principales: Perry, Thomas L, Pandey, Prativa, Grant, Jennifer M, Kain, Kevin C
Formato: Texto
Lenguaje:English
Publicado: Open Medicine Publications, Inc. 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765762/
https://www.ncbi.nlm.nih.gov/pubmed/19946387
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author Perry, Thomas L
Pandey, Prativa
Grant, Jennifer M
Kain, Kevin C
author_facet Perry, Thomas L
Pandey, Prativa
Grant, Jennifer M
Kain, Kevin C
author_sort Perry, Thomas L
collection PubMed
description BACKGROUND: We report the first case of atovaquone/proguanil treatment failure in severe Plasmodium falciparum malaria acquired by a non-immune traveller to the Indian subcontinent. Recrudescent infection was complicated by neurological involvement 14 days after directly observed therapy with atovaquone/proguanil. Sequence analysis of the plasmodial cytochrome b gene confirmed a contribution of atovaquone resistance to treatment failure. The recrudescent isolate had a single mutation at position 268 (Tyr268Cys). Video recordings illustrate dramatic but ephemeral manifestations of malaria with neurological involvement.
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spelling pubmed-27657622009-11-24 Severe atovaquone-resistant Plasmodium falciparum malaria in a Canadian traveller returned from the Indian subcontinent Perry, Thomas L Pandey, Prativa Grant, Jennifer M Kain, Kevin C Open Med Research BACKGROUND: We report the first case of atovaquone/proguanil treatment failure in severe Plasmodium falciparum malaria acquired by a non-immune traveller to the Indian subcontinent. Recrudescent infection was complicated by neurological involvement 14 days after directly observed therapy with atovaquone/proguanil. Sequence analysis of the plasmodial cytochrome b gene confirmed a contribution of atovaquone resistance to treatment failure. The recrudescent isolate had a single mutation at position 268 (Tyr268Cys). Video recordings illustrate dramatic but ephemeral manifestations of malaria with neurological involvement. Open Medicine Publications, Inc. 2009-01-20 /pmc/articles/PMC2765762/ /pubmed/19946387 Text en http://creativecommons.org/licenses/by-nc-sa/2.5/ca/ Open Medicine applies the Creative Commons Attribution Share Alike License, which means that anyone is able to freely copy, download, reprint, reuse, distribute, display or perform this work and that authors retain copyright of their work. Any derivative use of this work must be distributed only under a license identical to this one and must be attributed to the authors. Any of these conditions can be waived with permission from the copyright holder. These conditions do not negate or supersede Fair Use laws in any country.
spellingShingle Research
Perry, Thomas L
Pandey, Prativa
Grant, Jennifer M
Kain, Kevin C
Severe atovaquone-resistant Plasmodium falciparum malaria in a Canadian traveller returned from the Indian subcontinent
title Severe atovaquone-resistant Plasmodium falciparum malaria in a Canadian traveller returned from the Indian subcontinent
title_full Severe atovaquone-resistant Plasmodium falciparum malaria in a Canadian traveller returned from the Indian subcontinent
title_fullStr Severe atovaquone-resistant Plasmodium falciparum malaria in a Canadian traveller returned from the Indian subcontinent
title_full_unstemmed Severe atovaquone-resistant Plasmodium falciparum malaria in a Canadian traveller returned from the Indian subcontinent
title_short Severe atovaquone-resistant Plasmodium falciparum malaria in a Canadian traveller returned from the Indian subcontinent
title_sort severe atovaquone-resistant plasmodium falciparum malaria in a canadian traveller returned from the indian subcontinent
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765762/
https://www.ncbi.nlm.nih.gov/pubmed/19946387
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