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Drug-Virus Interaction: Effect of Administration of Recombinant Adenoviruses on the Pharmacokinetics of Docetaxel in a Rat Model

Modern cancer therapy combines recombinant viruses with traditional chemotherapeutic agents that are metabolized by hepatic cytochrome P450 3A4 (CYP3A4). A single dose of recombinant adenovirus (Ad) expressing beta-galactosidase (AdlacZ) significantly alters CYP3A2, the correlate of CYP3A4, in rats...

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Detalles Bibliográficos
Autores principales:	Wonganan, Piyanuch, Zamboni, William C., Strychor, Sandra A., Dekker, Joseph D., Croyle, Maria A.
Formato:	Texto
Lenguaje:	English
Publicado:	2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765861/ https://www.ncbi.nlm.nih.gov/pubmed/19110543 http://dx.doi.org/10.1038/cgt.2008.99

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