Cargando…

Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles

This commentary discusses a study on measurements of matrix metalloproteinase 9 (MMP-9) in serum of pseudoxanthoma elasticum patients recently published in Journal of Molecular Medicine. This study can be considered the typical "obstacle" to effective translational medicine as previously d...

Descripción completa

Detalles Bibliográficos
Autores principales: Jung, Klaus, Mannello, Ferdinando, Lein, Michael
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765947/
https://www.ncbi.nlm.nih.gov/pubmed/19828023
http://dx.doi.org/10.1186/1479-5876-7-87
_version_ 1782173178782547968
author Jung, Klaus
Mannello, Ferdinando
Lein, Michael
author_facet Jung, Klaus
Mannello, Ferdinando
Lein, Michael
author_sort Jung, Klaus
collection PubMed
description This commentary discusses a study on measurements of matrix metalloproteinase 9 (MMP-9) in serum of pseudoxanthoma elasticum patients recently published in Journal of Molecular Medicine. This study can be considered the typical "obstacle" to effective translational medicine as previously documented in JTM journal. Although serum has been frequently proven as inappropriate sample for determining numerous circulating MMPs, among them MMP-9, there are over and over again studies, as in this case, that measure MMP-9 in serum. Comparative measurements in serum and plasma samples demonstrated higher concentrations for MMP-9 in serum due to the additional release from leukocytes and platelets following the coagulation/fibrinolysis process. From this example it can be concluded that translating basic research discoveries into clinical tools needs a more intensive exchange between basic biomedical research and clinical scientists already in an early stage. Otherwise a lost of translation, as discussed in JTM journal, seems to be inevitable.
format Text
id pubmed-2765947
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-27659472009-10-23 Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles Jung, Klaus Mannello, Ferdinando Lein, Michael J Transl Med Commentary This commentary discusses a study on measurements of matrix metalloproteinase 9 (MMP-9) in serum of pseudoxanthoma elasticum patients recently published in Journal of Molecular Medicine. This study can be considered the typical "obstacle" to effective translational medicine as previously documented in JTM journal. Although serum has been frequently proven as inappropriate sample for determining numerous circulating MMPs, among them MMP-9, there are over and over again studies, as in this case, that measure MMP-9 in serum. Comparative measurements in serum and plasma samples demonstrated higher concentrations for MMP-9 in serum due to the additional release from leukocytes and platelets following the coagulation/fibrinolysis process. From this example it can be concluded that translating basic research discoveries into clinical tools needs a more intensive exchange between basic biomedical research and clinical scientists already in an early stage. Otherwise a lost of translation, as discussed in JTM journal, seems to be inevitable. BioMed Central 2009-10-14 /pmc/articles/PMC2765947/ /pubmed/19828023 http://dx.doi.org/10.1186/1479-5876-7-87 Text en Copyright © 2009 Jung et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Jung, Klaus
Mannello, Ferdinando
Lein, Michael
Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles
title Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles
title_full Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles
title_fullStr Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles
title_full_unstemmed Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles
title_short Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles
title_sort translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765947/
https://www.ncbi.nlm.nih.gov/pubmed/19828023
http://dx.doi.org/10.1186/1479-5876-7-87
work_keys_str_mv AT jungklaus translatingmolecularmedicineintoclinicaltoolsdoomedtofailbyneglectingbasicpreanalyticalprinciples
AT mannelloferdinando translatingmolecularmedicineintoclinicaltoolsdoomedtofailbyneglectingbasicpreanalyticalprinciples
AT leinmichael translatingmolecularmedicineintoclinicaltoolsdoomedtofailbyneglectingbasicpreanalyticalprinciples