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Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles
This commentary discusses a study on measurements of matrix metalloproteinase 9 (MMP-9) in serum of pseudoxanthoma elasticum patients recently published in Journal of Molecular Medicine. This study can be considered the typical "obstacle" to effective translational medicine as previously d...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765947/ https://www.ncbi.nlm.nih.gov/pubmed/19828023 http://dx.doi.org/10.1186/1479-5876-7-87 |
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author | Jung, Klaus Mannello, Ferdinando Lein, Michael |
author_facet | Jung, Klaus Mannello, Ferdinando Lein, Michael |
author_sort | Jung, Klaus |
collection | PubMed |
description | This commentary discusses a study on measurements of matrix metalloproteinase 9 (MMP-9) in serum of pseudoxanthoma elasticum patients recently published in Journal of Molecular Medicine. This study can be considered the typical "obstacle" to effective translational medicine as previously documented in JTM journal. Although serum has been frequently proven as inappropriate sample for determining numerous circulating MMPs, among them MMP-9, there are over and over again studies, as in this case, that measure MMP-9 in serum. Comparative measurements in serum and plasma samples demonstrated higher concentrations for MMP-9 in serum due to the additional release from leukocytes and platelets following the coagulation/fibrinolysis process. From this example it can be concluded that translating basic research discoveries into clinical tools needs a more intensive exchange between basic biomedical research and clinical scientists already in an early stage. Otherwise a lost of translation, as discussed in JTM journal, seems to be inevitable. |
format | Text |
id | pubmed-2765947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27659472009-10-23 Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles Jung, Klaus Mannello, Ferdinando Lein, Michael J Transl Med Commentary This commentary discusses a study on measurements of matrix metalloproteinase 9 (MMP-9) in serum of pseudoxanthoma elasticum patients recently published in Journal of Molecular Medicine. This study can be considered the typical "obstacle" to effective translational medicine as previously documented in JTM journal. Although serum has been frequently proven as inappropriate sample for determining numerous circulating MMPs, among them MMP-9, there are over and over again studies, as in this case, that measure MMP-9 in serum. Comparative measurements in serum and plasma samples demonstrated higher concentrations for MMP-9 in serum due to the additional release from leukocytes and platelets following the coagulation/fibrinolysis process. From this example it can be concluded that translating basic research discoveries into clinical tools needs a more intensive exchange between basic biomedical research and clinical scientists already in an early stage. Otherwise a lost of translation, as discussed in JTM journal, seems to be inevitable. BioMed Central 2009-10-14 /pmc/articles/PMC2765947/ /pubmed/19828023 http://dx.doi.org/10.1186/1479-5876-7-87 Text en Copyright © 2009 Jung et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Commentary Jung, Klaus Mannello, Ferdinando Lein, Michael Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles |
title | Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles |
title_full | Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles |
title_fullStr | Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles |
title_full_unstemmed | Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles |
title_short | Translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles |
title_sort | translating molecular medicine into clinical tools: doomed to fail by neglecting basic preanalytical principles |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765947/ https://www.ncbi.nlm.nih.gov/pubmed/19828023 http://dx.doi.org/10.1186/1479-5876-7-87 |
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