Screening for Microsatellite Instability Identifies Frequent 3′-Untranslated Region Mutation of the RB1-Inducible Coiled-Coil 1 Gene in Colon Tumors

BACKGROUND: Coding region microsatellite instability (MSI) results in loss of gene products and promotion of microsatellite-unstable (MSI-H) carcinogenesis. Recent studies have indicated that MSI within 3′-untranslated regions (3′UTRs) may post-transcriptionally dysregulate gene products. Within thi...

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Detalles Bibliográficos
Autores principales: Paun, Bogdan C., Cheng, Yulan, Leggett, Barbara A., Young, Joanne, Meltzer, Stephen J., Mori, Yuriko
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766054/
https://www.ncbi.nlm.nih.gov/pubmed/19888451
http://dx.doi.org/10.1371/journal.pone.0007715

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