Transformation of B cell lymphoma to histiocytic sarcoma: somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiation

Transdifferentiation of B cell lymphoma of germinal center cell origin to histiocytic sarcoma has recently been described but is a rare occurrence. The cause for loss of B cell differentiation in these lymphomas is unknown. We investigated whether somatic hypermutation of the PAX-5 gene, a transcrip...

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Detalles Bibliográficos
Autores principales: Bassarova, Assia, Trøen, Gunhild, Fosså, Alexander, Ikonomou, Ida Munster, Beiske, Klaus, Nesland, Jahn M., Delabie, Jan
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766441/
https://www.ncbi.nlm.nih.gov/pubmed/19669194
http://dx.doi.org/10.1007/s12308-009-0031-2
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author Bassarova, Assia
Trøen, Gunhild
Fosså, Alexander
Ikonomou, Ida Munster
Beiske, Klaus
Nesland, Jahn M.
Delabie, Jan
author_facet Bassarova, Assia
Trøen, Gunhild
Fosså, Alexander
Ikonomou, Ida Munster
Beiske, Klaus
Nesland, Jahn M.
Delabie, Jan
author_sort Bassarova, Assia
collection PubMed
description Transdifferentiation of B cell lymphoma of germinal center cell origin to histiocytic sarcoma has recently been described but is a rare occurrence. The cause for loss of B cell differentiation in these lymphomas is unknown. We investigated whether somatic hypermutation of the PAX-5 gene, a transcription factor that is important for maintaining B cell identity and is frequently mutated in B cell lymphomas of germinal center cell origin, might be a cause for loss of PAX-5 expression and thus B cell phenotype. However, no somatic hypermutation of the PAX-5 gene was detected in the two cases we studied. The molecular basis for transdifferentiation of B cell lymphoma to histiocytic sarcoma remains therefore unresolved.
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spelling pubmed-27664412009-10-26 Transformation of B cell lymphoma to histiocytic sarcoma: somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiation Bassarova, Assia Trøen, Gunhild Fosså, Alexander Ikonomou, Ida Munster Beiske, Klaus Nesland, Jahn M. Delabie, Jan J Hematop Original Article Transdifferentiation of B cell lymphoma of germinal center cell origin to histiocytic sarcoma has recently been described but is a rare occurrence. The cause for loss of B cell differentiation in these lymphomas is unknown. We investigated whether somatic hypermutation of the PAX-5 gene, a transcription factor that is important for maintaining B cell identity and is frequently mutated in B cell lymphomas of germinal center cell origin, might be a cause for loss of PAX-5 expression and thus B cell phenotype. However, no somatic hypermutation of the PAX-5 gene was detected in the two cases we studied. The molecular basis for transdifferentiation of B cell lymphoma to histiocytic sarcoma remains therefore unresolved. Springer-Verlag 2009-05-09 /pmc/articles/PMC2766441/ /pubmed/19669194 http://dx.doi.org/10.1007/s12308-009-0031-2 Text en © Springer-Verlag 2009
spellingShingle Original Article
Bassarova, Assia
Trøen, Gunhild
Fosså, Alexander
Ikonomou, Ida Munster
Beiske, Klaus
Nesland, Jahn M.
Delabie, Jan
Transformation of B cell lymphoma to histiocytic sarcoma: somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiation
title Transformation of B cell lymphoma to histiocytic sarcoma: somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiation
title_full Transformation of B cell lymphoma to histiocytic sarcoma: somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiation
title_fullStr Transformation of B cell lymphoma to histiocytic sarcoma: somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiation
title_full_unstemmed Transformation of B cell lymphoma to histiocytic sarcoma: somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiation
title_short Transformation of B cell lymphoma to histiocytic sarcoma: somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiation
title_sort transformation of b cell lymphoma to histiocytic sarcoma: somatic mutations of pax-5 gene with loss of expression cannot explain transdifferentiation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766441/
https://www.ncbi.nlm.nih.gov/pubmed/19669194
http://dx.doi.org/10.1007/s12308-009-0031-2
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