Transformation of B cell lymphoma to histiocytic sarcoma: somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiation

Transdifferentiation of B cell lymphoma of germinal center cell origin to histiocytic sarcoma has recently been described but is a rare occurrence. The cause for loss of B cell differentiation in these lymphomas is unknown. We investigated whether somatic hypermutation of the PAX-5 gene, a transcrip...

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Detalles Bibliográficos
Autores principales: Bassarova, Assia, Trøen, Gunhild, Fosså, Alexander, Ikonomou, Ida Munster, Beiske, Klaus, Nesland, Jahn M., Delabie, Jan
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766441/
https://www.ncbi.nlm.nih.gov/pubmed/19669194
http://dx.doi.org/10.1007/s12308-009-0031-2

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