Myelofibrosis involving lymph node: a novel cytogenetic abnormality in a mimicker of mesenchymal neoplasm

A case of primary myelofibrosis involving lymph node and with a novel cytogenetic abnormality [del (18) (p11.2-3)] is reported. The abnormalities are identical among specimens from the lymph node, peripheral blood, and bone marrow that were analyzed years apart. Additionally, we show that the infilt...

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Detalles Bibliográficos
Autores principales: Hu, Youjun, Zaslav, Ann-Leslie, Radhakrishnan, Neetu, Golightly, Marc, Pameijer, Colette
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766443/
https://www.ncbi.nlm.nih.gov/pubmed/19669186
http://dx.doi.org/10.1007/s12308-009-0040-1
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author Hu, Youjun
Zaslav, Ann-Leslie
Radhakrishnan, Neetu
Golightly, Marc
Pameijer, Colette
author_facet Hu, Youjun
Zaslav, Ann-Leslie
Radhakrishnan, Neetu
Golightly, Marc
Pameijer, Colette
author_sort Hu, Youjun
collection PubMed
description A case of primary myelofibrosis involving lymph node and with a novel cytogenetic abnormality [del (18) (p11.2-3)] is reported. The abnormalities are identical among specimens from the lymph node, peripheral blood, and bone marrow that were analyzed years apart. Additionally, we show that the infiltrate by dysplastic megakaryocytes in the lymph node morphologically mimics a metastatic mesenchymal neoplasm, even when the clinical history myelofibrosis was known.
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spelling pubmed-27664432009-10-26 Myelofibrosis involving lymph node: a novel cytogenetic abnormality in a mimicker of mesenchymal neoplasm Hu, Youjun Zaslav, Ann-Leslie Radhakrishnan, Neetu Golightly, Marc Pameijer, Colette J Hematop Case Report A case of primary myelofibrosis involving lymph node and with a novel cytogenetic abnormality [del (18) (p11.2-3)] is reported. The abnormalities are identical among specimens from the lymph node, peripheral blood, and bone marrow that were analyzed years apart. Additionally, we show that the infiltrate by dysplastic megakaryocytes in the lymph node morphologically mimics a metastatic mesenchymal neoplasm, even when the clinical history myelofibrosis was known. Springer-Verlag 2009-06-30 /pmc/articles/PMC2766443/ /pubmed/19669186 http://dx.doi.org/10.1007/s12308-009-0040-1 Text en © Springer-Verlag 2009
spellingShingle Case Report
Hu, Youjun
Zaslav, Ann-Leslie
Radhakrishnan, Neetu
Golightly, Marc
Pameijer, Colette
Myelofibrosis involving lymph node: a novel cytogenetic abnormality in a mimicker of mesenchymal neoplasm
title Myelofibrosis involving lymph node: a novel cytogenetic abnormality in a mimicker of mesenchymal neoplasm
title_full Myelofibrosis involving lymph node: a novel cytogenetic abnormality in a mimicker of mesenchymal neoplasm
title_fullStr Myelofibrosis involving lymph node: a novel cytogenetic abnormality in a mimicker of mesenchymal neoplasm
title_full_unstemmed Myelofibrosis involving lymph node: a novel cytogenetic abnormality in a mimicker of mesenchymal neoplasm
title_short Myelofibrosis involving lymph node: a novel cytogenetic abnormality in a mimicker of mesenchymal neoplasm
title_sort myelofibrosis involving lymph node: a novel cytogenetic abnormality in a mimicker of mesenchymal neoplasm
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766443/
https://www.ncbi.nlm.nih.gov/pubmed/19669186
http://dx.doi.org/10.1007/s12308-009-0040-1
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AT golightlymarc myelofibrosisinvolvinglymphnodeanovelcytogeneticabnormalityinamimickerofmesenchymalneoplasm
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