Oncogenic RAS Enables DNA Damage- and p53-Dependent Differentiation of Acute Myeloid Leukemia Cells in Response to Chemotherapy

Acute myeloid leukemia (AML) is a clonal disease originating from myeloid progenitor cells with a heterogeneous genetic background. High-dose cytarabine is used as the standard consolidation chemotherapy. Oncogenic RAS mutations are frequently observed in AML, and are associated with beneficial resp...

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Detalles Bibliográficos
Autores principales: Meyer, Mona, Rübsamen, Daniela, Slany, Robert, Illmer, Thomas, Stabla, Kathleen, Roth, Petra, Stiewe, Thorsten, Eilers, Martin, Neubauer, Andreas
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767509/
https://www.ncbi.nlm.nih.gov/pubmed/19890398
http://dx.doi.org/10.1371/journal.pone.0007768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767509/
https://www.ncbi.nlm.nih.gov/pubmed/19890398
http://dx.doi.org/10.1371/journal.pone.0007768

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