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Oncogenic RAS Enables DNA Damage- and p53-Dependent Differentiation of Acute Myeloid Leukemia Cells in Response to Chemotherapy

Acute myeloid leukemia (AML) is a clonal disease originating from myeloid progenitor cells with a heterogeneous genetic background. High-dose cytarabine is used as the standard consolidation chemotherapy. Oncogenic RAS mutations are frequently observed in AML, and are associated with beneficial resp...

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Detalles Bibliográficos
Autores principales:	Meyer, Mona, Rübsamen, Daniela, Slany, Robert, Illmer, Thomas, Stabla, Kathleen, Roth, Petra, Stiewe, Thorsten, Eilers, Martin, Neubauer, Andreas
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767509/ https://www.ncbi.nlm.nih.gov/pubmed/19890398 http://dx.doi.org/10.1371/journal.pone.0007768

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