The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro

BACKGROUND: Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear. METHODS: Immunohistochemical analysis of fascin expression was carried out in resected human colorectal adenoma specimens. The effects of...

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Detalles Bibliográficos
Autores principales: Qualtrough, D, Singh, K, Banu, N, Paraskeva, C, Pignatelli, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768091/
https://www.ncbi.nlm.nih.gov/pubmed/19738613
http://dx.doi.org/10.1038/sj.bjc.6605286
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author Qualtrough, D
Singh, K
Banu, N
Paraskeva, C
Pignatelli, M
author_facet Qualtrough, D
Singh, K
Banu, N
Paraskeva, C
Pignatelli, M
author_sort Qualtrough, D
collection PubMed
description BACKGROUND: Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear. METHODS: Immunohistochemical analysis of fascin expression was carried out in resected human colorectal adenoma specimens. The effects of forced overexpression of fascin on adenoma cell motility were also analysed. RESULTS: We show fascin overexpression in adenomas increasing with tumour size, histological type, and degree of dysplasia and increased cell motility in adenoma cell lines following fascin transfection. CONCLUSION: These data suggest an important role for fascin in the malignant progression of colorectal tumours.
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spelling pubmed-27680912010-10-06 The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro Qualtrough, D Singh, K Banu, N Paraskeva, C Pignatelli, M Br J Cancer Short Communication BACKGROUND: Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear. METHODS: Immunohistochemical analysis of fascin expression was carried out in resected human colorectal adenoma specimens. The effects of forced overexpression of fascin on adenoma cell motility were also analysed. RESULTS: We show fascin overexpression in adenomas increasing with tumour size, histological type, and degree of dysplasia and increased cell motility in adenoma cell lines following fascin transfection. CONCLUSION: These data suggest an important role for fascin in the malignant progression of colorectal tumours. Nature Publishing Group 2009-10-06 2009-09-08 /pmc/articles/PMC2768091/ /pubmed/19738613 http://dx.doi.org/10.1038/sj.bjc.6605286 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Qualtrough, D
Singh, K
Banu, N
Paraskeva, C
Pignatelli, M
The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro
title The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro
title_full The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro
title_fullStr The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro
title_full_unstemmed The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro
title_short The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro
title_sort actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768091/
https://www.ncbi.nlm.nih.gov/pubmed/19738613
http://dx.doi.org/10.1038/sj.bjc.6605286
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