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Serum triglyceride concentrations and cancer risk in a large cohort study in Austria

BACKGROUND: Blood lipid levels as part of the metabolic syndrome are thought to be linked to cancer risk. Few epidemiological studies have addressed the association between serum triglyceride (STG) concentrations and cancer risk. METHODS: Serum triglyceride concentrations were collected in a health...

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Autores principales: Ulmer, H, Borena, W, Rapp, K, Klenk, J, Strasak, A, Diem, G, Concin, H, Nagel, G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768093/
https://www.ncbi.nlm.nih.gov/pubmed/19690552
http://dx.doi.org/10.1038/sj.bjc.6605264
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author Ulmer, H
Borena, W
Rapp, K
Klenk, J
Strasak, A
Diem, G
Concin, H
Nagel, G
author_facet Ulmer, H
Borena, W
Rapp, K
Klenk, J
Strasak, A
Diem, G
Concin, H
Nagel, G
author_sort Ulmer, H
collection PubMed
description BACKGROUND: Blood lipid levels as part of the metabolic syndrome are thought to be linked to cancer risk. Few epidemiological studies have addressed the association between serum triglyceride (STG) concentrations and cancer risk. METHODS: Serum triglyceride concentrations were collected in a health investigation (1988–2003). The analyses included 156 153 subjects (71 693 men and 84 460 women), with 5079 incident cancers in men and 4738 cancers in women, and an average of 10.6 years of follow-up. All malignancies were ascertained from the population cancer registry. Multivariate Cox proportional hazard models stratified by age and sex were used to determine adjusted cancer risk estimates and 95% confidence interval (95% CI). RESULTS: In men and women combined, higher STG concentrations were associated with increased risk of lung (4th vs 1st quartile: HR, 1.94; 95% CI, 1.47–2.54), rectal (HR, 1.56; 95% CI, 1.00–2.44), and thyroid cancer (HR, 1.96; 95% CI, 1.00–3.84). Serum triglyceride concentrations were inversely associated with non-Hodgkin's lymphoma. In men, STG concentrations were inversely associated with prostate cancer and positively with renal cancer. In women, STG concentrations were positively associated with gynaecological cancers. Stratification by BMI revealed a higher risk of gynaecological cancers in overweight than in normal weight women. No other associations were found. CONCLUSIONS: Our findings support the hypothesis that STG concentrations are involved in the pathogenesis of lung, rectal, thyroid, prostate, and gynaecological cancers.
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spelling pubmed-27680932010-10-06 Serum triglyceride concentrations and cancer risk in a large cohort study in Austria Ulmer, H Borena, W Rapp, K Klenk, J Strasak, A Diem, G Concin, H Nagel, G Br J Cancer Epidemiology BACKGROUND: Blood lipid levels as part of the metabolic syndrome are thought to be linked to cancer risk. Few epidemiological studies have addressed the association between serum triglyceride (STG) concentrations and cancer risk. METHODS: Serum triglyceride concentrations were collected in a health investigation (1988–2003). The analyses included 156 153 subjects (71 693 men and 84 460 women), with 5079 incident cancers in men and 4738 cancers in women, and an average of 10.6 years of follow-up. All malignancies were ascertained from the population cancer registry. Multivariate Cox proportional hazard models stratified by age and sex were used to determine adjusted cancer risk estimates and 95% confidence interval (95% CI). RESULTS: In men and women combined, higher STG concentrations were associated with increased risk of lung (4th vs 1st quartile: HR, 1.94; 95% CI, 1.47–2.54), rectal (HR, 1.56; 95% CI, 1.00–2.44), and thyroid cancer (HR, 1.96; 95% CI, 1.00–3.84). Serum triglyceride concentrations were inversely associated with non-Hodgkin's lymphoma. In men, STG concentrations were inversely associated with prostate cancer and positively with renal cancer. In women, STG concentrations were positively associated with gynaecological cancers. Stratification by BMI revealed a higher risk of gynaecological cancers in overweight than in normal weight women. No other associations were found. CONCLUSIONS: Our findings support the hypothesis that STG concentrations are involved in the pathogenesis of lung, rectal, thyroid, prostate, and gynaecological cancers. Nature Publishing Group 2009-10-06 2009-08-18 /pmc/articles/PMC2768093/ /pubmed/19690552 http://dx.doi.org/10.1038/sj.bjc.6605264 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Ulmer, H
Borena, W
Rapp, K
Klenk, J
Strasak, A
Diem, G
Concin, H
Nagel, G
Serum triglyceride concentrations and cancer risk in a large cohort study in Austria
title Serum triglyceride concentrations and cancer risk in a large cohort study in Austria
title_full Serum triglyceride concentrations and cancer risk in a large cohort study in Austria
title_fullStr Serum triglyceride concentrations and cancer risk in a large cohort study in Austria
title_full_unstemmed Serum triglyceride concentrations and cancer risk in a large cohort study in Austria
title_short Serum triglyceride concentrations and cancer risk in a large cohort study in Austria
title_sort serum triglyceride concentrations and cancer risk in a large cohort study in austria
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768093/
https://www.ncbi.nlm.nih.gov/pubmed/19690552
http://dx.doi.org/10.1038/sj.bjc.6605264
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