Cargando…

Vascular Endothelial Growth Factor Inhibition by dRK6 Causes Endothelial Apoptosis, Fibrosis, and Inflammation in the Heart via the Akt/eNOS Axis in db/db Mice

OBJECTIVE: Vascular endothelial growth factor (VEGF), which is associated with the stimulation of angiogenesis and collateral vessel synthase, is one of the crucial factors involved in cardiac remodeling in type 2 diabetes. RESEARCH DESIGN AND METHODS: We investigated VEGF inhibition by dRK6 on the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Whee Park, Cheol, Wook Kim, Hyung, Hee Lim, Ji, Dong Yoo, Ki, Chung, Sungjin, Joon Shin, Seok, Wha Chung, Hyun, Ju Lee, Sang, Chae, Chi-Bom, Kim, Yong-Soo, Sik Chang, Yoon
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768173/ https://www.ncbi.nlm.nih.gov/pubmed/19675133 http://dx.doi.org/10.2337/db09-0136

Ejemplares similares

Vascular Endothelial Growth Factor-Receptor 1 Inhibition Aggravates Diabetic Nephropathy through eNOS Signaling Pathway in db/db Mice
por: Yang, Keun Suk, et al.
Publicado: (2014)

Acarbose Accelerates Wound Healing via Akt/eNOS Signaling in db/db Mice
por: Han, Xue, et al.
Publicado: (2017)

Therapeutic Effects of Fenofibrate on Diabetic Peripheral Neuropathy by Improving Endothelial and Neural Survival in db/db Mice
por: Cho, Ye Rim, et al.
Publicado: (2014)

Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
por: Hong, Yu Ah, et al.
Publicado: (2014)

Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy
por: Lim, Ji Hee, et al.
Publicado: (2018)

Inhibition of lymphatic proliferation by the selective VEGFR-3 inhibitor SAR131675 ameliorates diabetic nephropathy in db/db mice
por: Hwang, Seun Deuk, et al.
Publicado: (2019)

Neurogranin regulates eNOS function and endothelial activation
por: Cheriyan, Vino T., et al.
Publicado: (2020)

Redox Signaling and Regional Heterogeneity of Endothelial Dysfunction in db/db Mice
por: Sallam, Nada A., et al.
Publicado: (2020)

Chronic Resveratrol Treatment Protects Pancreatic Islets against Oxidative Stress in db/db Mice
por: Lee, Young-Eun, et al.
Publicado: (2012)

Portulaca oleracea Ameliorates Diabetic Vascular Inflammation and Endothelial Dysfunction in db/db Mice
por: Lee, An Sook, et al.
Publicado: (2012)

Inhibition of acid sphingomyelinase activity ameliorates endothelial dysfunction in db/db mice
por: Jiang, Meng, et al.
Publicado: (2019)

Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in db/db mice
por: Srivastava, Swayam Prakash, et al.
Publicado: (2023)

Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in db/db mice
por: Srivastava, Swayam Prakash, et al.
Publicado: (2023)

Endothelial Dysfunction and Passive Changes in the Aorta and Coronary Arteries of Diabetic db/db Mice
por: Beck, Lilliana, et al.
Publicado: (2020)

Endothelial microparticles prevent lipid-induced endothelial damage via Akt/eNOS signaling and reduced oxidative stress
por: Mahmoud, Ayman M., et al.
Publicado: (2017)

Endothelial cell-specific loss of eNOS differentially affects endothelial function
por: Bu, Shuhan, et al.
Publicado: (2022)

Multiple inducers of endothelial NOS (eNOS) dysfunction in sickle cell disease
por: Hebbel, Robert P., et al.
Publicado: (2021)

Total flavonoids from Astragalus alleviate endothelial dysfunction by activating the Akt/eNOS pathway
por: Liu, Qian, et al.
Publicado: (2017)

Betaine Alleviates Hypertriglycemia and Tau Hyperphosphorylation in db/db Mice
por: Jung, Ga-young, et al.
Publicado: (2013)

AFM-based detection of glycocalyx degradation and endothelial stiffening in the db/db mouse model of diabetes
por: Targosz-Korecka, Marta, et al.
Publicado: (2017)

Antihyperglycemic and Antiobesity Effects of JAL2 on db/db Mice
por: Lee, In-Seung, et al.
Publicado: (2016)

The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function
por: Alghanem, Ahmad F, et al.
Publicado: (2021)

Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db mice
por: Cheng, Huifang, et al.
Publicado: (2012)

Rosiglitazone accelerates wound healing by improving endothelial precursor cell function and angiogenesis in db/db mice
por: Zhou, Guoliang, et al.
Publicado: (2019)

PKC-Dependent Phosphorylation of eNOS at T495 Regulates eNOS Coupling and Endothelial Barrier Function in Response to G(+) -Toxins
por: Chen, Feng, et al.
Publicado: (2014)

Endothelial NO Production Is Mandatory for Epigallocatechin-3-Gallate–induced Vasodilation: Results From eNOS Knockout (eNOS(−/−)) Mice
por: Lorenz, Mario, et al.
Publicado: (2015)

Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells
por: Chen, Zhenlong, et al.
Publicado: (2018)

Sex-specific eNOS activity and function in human endothelial cells
por: Cattaneo, Maria Grazia, et al.
Publicado: (2017)

Endothelial CaMKII as a regulator of eNOS activity and NO-mediated vasoreactivity
por: Murthy, Shubha, et al.
Publicado: (2017)

Alpha‐mangostin improves endothelial dysfunction in db/db mice through inhibition of aSMase/ceramide pathway
por: Jiang, Meng, et al.
Publicado: (2021)

Endothelial S1pr2 regulates post-ischemic angiogenesis via AKT/eNOS signaling pathway
por: Zhou, Caixia, et al.
Publicado: (2022)

Microbiota-governed microRNA-204 impairs endothelial function and blood pressure decline during inactivity in db/db mice
por: Gaddam, Ravinder Reddy, et al.
Publicado: (2020)

Activation of Endothelial Nitric Oxide (eNOS) Occurs through Different Membrane Domains in Endothelial Cells
por: Tran, Jason, et al.
Publicado: (2016)

EndoDB: a database of endothelial cell transcriptomics data
por: Khan, Shawez, et al.
Publicado: (2019)

Effects of cranberry powder on biomarkers of oxidative stress and glucose control in db/db mice
por: Kim, Mi Joung, et al.
Publicado: (2013)

Extensive Ethnogenomic Diversity of Endothelial Nitric Oxide Synthase (eNOS) Polymorphisms
por: Thomas, Bolaji N., et al.
Publicado: (2013)

Stachydrine protects eNOS uncoupling and ameliorates endothelial dysfunction induced by homocysteine
por: Xie, Xinya, et al.
Publicado: (2018)

Endothelial lipase increases eNOS activating capacity of high-density lipoprotein
por: Radulović, Snježana, et al.
Publicado: (2020)

Acute Mechanical Stretch Promotes eNOS Activation in Venous Endothelial Cells Mainly via PKA and Akt Pathways
por: Hu, Zhenqian, et al.
Publicado: (2013)

Crocetin promotes angiogenesis in human endothelial cells through PI3K-Akt-eNOS signaling pathway
por: Nasirzadeh, Mahdieh, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ppf6a7r2m1r7dbse0cu7494qfg