Cargando…

Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene

OBJECTIVE: In a genome-wide association scan, the rs738409 C>G single nucleotide polymorphism (SNP) in the patatin-like phospholipase 3 gene (PNPLA3) was strongly associated with increased liver fat but not with insulin resistance estimated from fasting values. We investigated whether the SNP det...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kantartzis, Konstantinos, Peter, Andreas, Machicao, Fausto, Machann, Jürgen, Wagner, Silvia, Königsrainer, Ingmar, Königsrainer, Alfred, Schick, Fritz, Fritsche, Andreas, Häring, Hans-Ulrich, Stefan, Norbert
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768178/ https://www.ncbi.nlm.nih.gov/pubmed/19651814 http://dx.doi.org/10.2337/db09-0279

Ejemplares similares

Glucose-Raising Polymorphisms in the Human Clock Gene Cryptochrome 2 (CRY2) Affect Hepatic Lipid Content
por: Machicao, Fausto, et al.
Publicado: (2016)

Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans
por: Peter, Andreas, et al.
Publicado: (2010)

SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention – the TULIP Study
por: Weyrich, Peter, et al.
Publicado: (2008)

Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans
por: Randrianarisoa, Elko, et al.
Publicado: (2016)

No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes
por: Müssig, Karsten, et al.
Publicado: (2010)

Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans
por: Staiger, Harald, et al.
Publicado: (2009)

Dietary Niacin Intake Predicts the Decrease of Liver Fat Content During a Lifestyle Intervention
por: Linder, Katarzyna, et al.
Publicado: (2019)

Cholesterol Synthesis Is Associated with Hepatic Lipid Content and Dependent on Fructose/Glucose Intake in Healthy Humans
por: Silbernagel, Guenther, et al.
Publicado: (2012)

Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans
por: Lutz, Stefan Z., et al.
Publicado: (2018)

Common Genetic Variation in the Human CTF1 Locus, Encoding Cardiotrophin-1, Determines Insulin Sensitivity
por: Lutz, Stefan Z., et al.
Publicado: (2014)

Circulating Palmitoleate Strongly and Independently Predicts Insulin Sensitivity in Humans
por: Stefan, Norbert, et al.
Publicado: (2010)

Common Genetic Variation in the SERPINF1 Locus Determines Overall Adiposity, Obesity-Related Insulin Resistance, and Circulating Leptin Levels
por: Böhm, Anja, et al.
Publicado: (2012)

Circulating Lysophosphatidylcholines Are Markers of a Metabolically Benign Nonalcoholic Fatty Liver
por: Lehmann, Rainer, et al.
Publicado: (2013)

The D299G/T399I Toll-Like Receptor 4 Variant Associates with Body and Liver Fat: Results from the TULIP and METSIM Studies
por: Weyrich, Peter, et al.
Publicado: (2010)

Gene Variants of TCF7L2 Influence Weight Loss and Body Composition During Lifestyle Intervention in a Population at Risk for Type 2 Diabetes
por: Haupt, Axel, et al.
Publicado: (2010)

Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL-Cholesterol without Modification of Metabolic or Inflammatory Markers
por: Kächele, Martin, et al.
Publicado: (2015)

Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo
por: Peter, Andreas, et al.
Publicado: (2009)

Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity
por: Staiger, Harald, et al.
Publicado: (2013)

Pancreatic Steatosis Associates With Impaired Insulin Secretion in Genetically Predisposed Individuals
por: Wagner, Róbert, et al.
Publicado: (2020)

Novel Meta-Analysis-Derived Type 2 Diabetes Risk Loci Do Not Determine Prediabetic Phenotypes
por: Staiger, Harald, et al.
Publicado: (2008)

Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function
por: Staiger, Harald, et al.
Publicado: (2008)

Polymorphisms within Novel Risk Loci for Type 2 Diabetes Determine β-Cell Function
por: Staiger, Harald, et al.
Publicado: (2007)

Evaluation of Fasting State-/Oral Glucose Tolerance Test-Derived Measures of Insulin Release for the Detection of Genetically Impaired β-Cell Function
por: Herzberg-Schäfer, Silke A., et al.
Publicado: (2010)

Free fatty acids, glicentin and glucose-dependent insulinotropic polypeptide as potential major determinants of fasting substrate oxidation
por: Hummel, Julia, et al.
Publicado: (2021)

Lower Hepatic Fat Is Associated With Improved Insulin Secretion in a High-Risk Prediabetes Subphenotype During Lifestyle Intervention
por: Wagner, Robert, et al.
Publicado: (2023)

Normalized Indices Derived from Visceral Adipose Mass Assessed by Magnetic Resonance Imaging and Their Correlation with Markers for Insulin Resistance and Prediabetes
por: Machann, Jürgen, et al.
Publicado: (2020)

Right Hemihepatectomy by Suprahilar Intrahepatic Transection of the Right Hemipedicle using a Vascular Stapler
por: Königsrainer, Ingmar, et al.
Publicado: (2010)

Diabetes Mellitus and Prediabetes on Kidney Transplant Waiting List- Prevalence, Metabolic Phenotyping and Risk Stratification Approach
por: Guthoff, Martina, et al.
Publicado: (2015)

Association of Type 2 Diabetes Candidate Polymorphisms in KCNQ1 With Incretin and Insulin Secretion
por: Müssig, Karsten, et al.
Publicado: (2009)

Dietary Fiber Intake Modulates the Association Between Variants in TCF7L2 and Weight Loss During a Lifestyle Intervention
por: Heni, Martin, et al.
Publicado: (2012)

Glucose-Raising Genetic Variants in MADD and ADCY5 Impair Conversion of Proinsulin to Insulin
por: Wagner, Robert, et al.
Publicado: (2011)

Fetuin-A Induces Cytokine Expression and Suppresses Adiponectin Production
por: Hennige, Anita M., et al.
Publicado: (2008)

Extracellular Matrix Expression in Human Pancreatic Fat Cells of Patients with Normal Glucose Regulation, Prediabetes and Type 2 Diabetes
por: Siegel-Axel, Dorothea, et al.
Publicado: (2023)

A Toxoplasma gondii patatin-like phospholipase contributes to host cell invasion
por: Wilson, Sarah K., et al.
Publicado: (2020)

Lower Plasma Creatinine and Urine Albumin in Individuals at Increased Risk of Type 2 Diabetes with Factor V Leiden Mutation
por: Peter, Andreas, et al.
Publicado: (2014)

FTO Genotype Interacts with Improvement in Aerobic Fitness on Body Weight Loss During Lifestyle Intervention
por: Sailer, Corinna, et al.
Publicado: (2016)

DPP4 gene variation affects GLP-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity
por: Böhm, Anja, et al.
Publicado: (2017)

Initial Clinical Experience with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Signet-Ring Cell Gastric Cancer with Peritoneal Metastases
por: Königsrainer, Ingmar, et al.
Publicado: (2014)

Twelve-Year Single Center Experience Shows Safe Implementation of Developed Peritoneal Surface Malignancy Treatment Protocols for Gastrointestinal and Gynecological Primary Tumors
por: Horvath, Philipp, et al.
Publicado: (2021)

Overexpression of patatin-related phospholipase AIIIβ altered the content and composition of sphingolipids in Arabidopsis
por: Li, Maoyin, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ft29c4rr5tm25l5ne4c61qccm2