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11β-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle

OBJECTIVE: Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown. Within skeletal muscle, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts cortisone (11-dehydrocorticosterone in rodents) t...

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Detalles Bibliográficos
Autores principales:	Morgan, Stuart A., Sherlock, Mark, Gathercole, Laura L., Lavery, Gareth G., Lenaghan, Carol, Bujalska, Iwona J., Laber, David, Yu, Alice, Convey, Gemma, Mayers, Rachel, Hegyi, Krisztina, Sethi, Jaswinder K., Stewart, Paul M., Smith, David M., Tomlinson, Jeremy W.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768185/ https://www.ncbi.nlm.nih.gov/pubmed/19675138 http://dx.doi.org/10.2337/db09-0525

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