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Insulin Sensitivity as an Independent Predictor of Fat Mass Gain in Hispanic Adolescents
OBJECTIVE: The purpose of this study was to examine the relationship between changes in insulin sensitivity and subsequent changes in fat mass in obese Hispanic children over 3 consecutive years. RESEARCH DESIGN AND METHODS: In a longitudinal research design, insulin sensitivity (S(i)) of 96 researc...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768217/ https://www.ncbi.nlm.nih.gov/pubmed/19675204 http://dx.doi.org/10.2337/dc09-0833 |
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author | Adam, Tanja C. Toledo-Corral, Claudia Lane, Christianne J. Weigensberg, Marc J. Spruijt-Metz, Donna Davies, Jaimie N. Goran, Michael I. |
author_facet | Adam, Tanja C. Toledo-Corral, Claudia Lane, Christianne J. Weigensberg, Marc J. Spruijt-Metz, Donna Davies, Jaimie N. Goran, Michael I. |
author_sort | Adam, Tanja C. |
collection | PubMed |
description | OBJECTIVE: The purpose of this study was to examine the relationship between changes in insulin sensitivity and subsequent changes in fat mass in obese Hispanic children over 3 consecutive years. RESEARCH DESIGN AND METHODS: In a longitudinal research design, insulin sensitivity (S(i)) of 96 research participants was determined at baseline and 1 year later. Body adiposity was assessed at four assessments. RESULTS: The change in S(i) during the first year of the study was a significant predictor of further fat mass development (P < 0.05). Considering different directions of S(i) change, S(i) was a strong predictor for further fat mass development only in the group that decreased their S(i) (P < 0.05). CONCLUSIONS: The results show that the direction of change in insulin sensitivity at an early age is an important independent predictor for further fat mass development and emphasize the importance of insulin sensitivity as a primary target for long-term obesity prevention, as well as the significance of early age intervention. |
format | Text |
id | pubmed-2768217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-27682172010-11-01 Insulin Sensitivity as an Independent Predictor of Fat Mass Gain in Hispanic Adolescents Adam, Tanja C. Toledo-Corral, Claudia Lane, Christianne J. Weigensberg, Marc J. Spruijt-Metz, Donna Davies, Jaimie N. Goran, Michael I. Diabetes Care Original Research OBJECTIVE: The purpose of this study was to examine the relationship between changes in insulin sensitivity and subsequent changes in fat mass in obese Hispanic children over 3 consecutive years. RESEARCH DESIGN AND METHODS: In a longitudinal research design, insulin sensitivity (S(i)) of 96 research participants was determined at baseline and 1 year later. Body adiposity was assessed at four assessments. RESULTS: The change in S(i) during the first year of the study was a significant predictor of further fat mass development (P < 0.05). Considering different directions of S(i) change, S(i) was a strong predictor for further fat mass development only in the group that decreased their S(i) (P < 0.05). CONCLUSIONS: The results show that the direction of change in insulin sensitivity at an early age is an important independent predictor for further fat mass development and emphasize the importance of insulin sensitivity as a primary target for long-term obesity prevention, as well as the significance of early age intervention. American Diabetes Association 2009-11 2009-08-12 /pmc/articles/PMC2768217/ /pubmed/19675204 http://dx.doi.org/10.2337/dc09-0833 Text en © 2009 by the American Diabetes Association. https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ (https://creativecommons.org/licenses/by-nc-nd/3.0/) for details. |
spellingShingle | Original Research Adam, Tanja C. Toledo-Corral, Claudia Lane, Christianne J. Weigensberg, Marc J. Spruijt-Metz, Donna Davies, Jaimie N. Goran, Michael I. Insulin Sensitivity as an Independent Predictor of Fat Mass Gain in Hispanic Adolescents |
title | Insulin Sensitivity as an Independent Predictor of Fat Mass Gain in Hispanic Adolescents |
title_full | Insulin Sensitivity as an Independent Predictor of Fat Mass Gain in Hispanic Adolescents |
title_fullStr | Insulin Sensitivity as an Independent Predictor of Fat Mass Gain in Hispanic Adolescents |
title_full_unstemmed | Insulin Sensitivity as an Independent Predictor of Fat Mass Gain in Hispanic Adolescents |
title_short | Insulin Sensitivity as an Independent Predictor of Fat Mass Gain in Hispanic Adolescents |
title_sort | insulin sensitivity as an independent predictor of fat mass gain in hispanic adolescents |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768217/ https://www.ncbi.nlm.nih.gov/pubmed/19675204 http://dx.doi.org/10.2337/dc09-0833 |
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