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Significant Synergistic Effect of Peroxisome Proliferator–Activated Receptor γ C-2821T and Diabetes on the Risk of Ischemic Stroke
OBJECTIVE: To explore the relationship between the genetic polymorphisms of PPARγ (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPARγ would modify the risk of ischemic stroke among patients with hypertension or diabetes. RES...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768222/ https://www.ncbi.nlm.nih.gov/pubmed/19651920 http://dx.doi.org/10.2337/dc09-0717 |
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author | Hsieh, Fang-I Lo, Wei-Cheng Lin, Huey-Juan Hsieh, Yi-Chen Lien, Li-Ming Bai, Chyi-Huey Tseng, Hung-Pin Chiou, Hung-Yi |
author_facet | Hsieh, Fang-I Lo, Wei-Cheng Lin, Huey-Juan Hsieh, Yi-Chen Lien, Li-Ming Bai, Chyi-Huey Tseng, Hung-Pin Chiou, Hung-Yi |
author_sort | Hsieh, Fang-I |
collection | PubMed |
description | OBJECTIVE: To explore the relationship between the genetic polymorphisms of PPARγ (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPARγ would modify the risk of ischemic stroke among patients with hypertension or diabetes. RESEARCH DESIGN AND METHODS: The case-control study was conducted with 537 ischemic stroke patients and 537 control subjects. A structured questionnaire was used to collect information on conventional cardiovascular risk factors and laboratory results. The genetic polymorphisms of PPARγ were determined by PCR–restriction fragment–length polymorphism. RESULTS: A significant interaction was seen between the −2821C allele and diabetes but not between this allele and hypertension. A markedly elevated risk of ischemic stroke (odds ratio 9.7) was found in the subjects with diabetes and the −2821C allele compared with that in those without these two risk factors. CONCLUSIONS: The −2821C allele of PPARγ was a strong predictor of ischemic stroke for diabetic patients. |
format | Text |
id | pubmed-2768222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-27682222010-11-01 Significant Synergistic Effect of Peroxisome Proliferator–Activated Receptor γ C-2821T and Diabetes on the Risk of Ischemic Stroke Hsieh, Fang-I Lo, Wei-Cheng Lin, Huey-Juan Hsieh, Yi-Chen Lien, Li-Ming Bai, Chyi-Huey Tseng, Hung-Pin Chiou, Hung-Yi Diabetes Care Original Research OBJECTIVE: To explore the relationship between the genetic polymorphisms of PPARγ (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPARγ would modify the risk of ischemic stroke among patients with hypertension or diabetes. RESEARCH DESIGN AND METHODS: The case-control study was conducted with 537 ischemic stroke patients and 537 control subjects. A structured questionnaire was used to collect information on conventional cardiovascular risk factors and laboratory results. The genetic polymorphisms of PPARγ were determined by PCR–restriction fragment–length polymorphism. RESULTS: A significant interaction was seen between the −2821C allele and diabetes but not between this allele and hypertension. A markedly elevated risk of ischemic stroke (odds ratio 9.7) was found in the subjects with diabetes and the −2821C allele compared with that in those without these two risk factors. CONCLUSIONS: The −2821C allele of PPARγ was a strong predictor of ischemic stroke for diabetic patients. American Diabetes Association 2009-11 2009-08-03 /pmc/articles/PMC2768222/ /pubmed/19651920 http://dx.doi.org/10.2337/dc09-0717 Text en © 2009 by the American Diabetes Association. https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ (https://creativecommons.org/licenses/by-nc-nd/3.0/) for details. |
spellingShingle | Original Research Hsieh, Fang-I Lo, Wei-Cheng Lin, Huey-Juan Hsieh, Yi-Chen Lien, Li-Ming Bai, Chyi-Huey Tseng, Hung-Pin Chiou, Hung-Yi Significant Synergistic Effect of Peroxisome Proliferator–Activated Receptor γ C-2821T and Diabetes on the Risk of Ischemic Stroke |
title | Significant Synergistic Effect of Peroxisome Proliferator–Activated Receptor γ C-2821T and Diabetes on the Risk of Ischemic Stroke |
title_full | Significant Synergistic Effect of Peroxisome Proliferator–Activated Receptor γ C-2821T and Diabetes on the Risk of Ischemic Stroke |
title_fullStr | Significant Synergistic Effect of Peroxisome Proliferator–Activated Receptor γ C-2821T and Diabetes on the Risk of Ischemic Stroke |
title_full_unstemmed | Significant Synergistic Effect of Peroxisome Proliferator–Activated Receptor γ C-2821T and Diabetes on the Risk of Ischemic Stroke |
title_short | Significant Synergistic Effect of Peroxisome Proliferator–Activated Receptor γ C-2821T and Diabetes on the Risk of Ischemic Stroke |
title_sort | significant synergistic effect of peroxisome proliferator–activated receptor γ c-2821t and diabetes on the risk of ischemic stroke |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768222/ https://www.ncbi.nlm.nih.gov/pubmed/19651920 http://dx.doi.org/10.2337/dc09-0717 |
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