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Synergistic anti-cancer effects of immunotoxin and cyclosporin in vitro and in vivo

BACKGROUND: The clinical use of immunotoxins (ITs) has been hampered by hepatotoxicity, and the induction of a strong human-anti-IT response. The human-anti-IT response results in neutralisation of the immunoconjugates, rendering repetitive treatment inefficacious. METHODS: We evaluated the combinat...

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Detalles Bibliográficos
Autores principales:	Andersson, Y, Engebraaten, O, Fodstad, Ø
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768448/ https://www.ncbi.nlm.nih.gov/pubmed/19773757 http://dx.doi.org/10.1038/sj.bjc.6605312

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