Phosphoinositide-dependent kinase 1 integrates T cell receptor and CD28 co-receptor signaling to effect NF-κB induction and T cell activation

In addition to T cell receptor (TCR) ligation, activation of CD28 coreceptor by costimulatory molecule B7 is required for transcription factor NF-κB induction and robust T cell activation, though exactly how CD28 contributes to this remains incompletely understood. We demonstrated here that phosphoi...

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Detalles Bibliográficos
Autores principales: Park, Sung-Gyoo, Schulze-Luehrman, Jan, Hayden, Matthew S., Hashimoto, Naoko, Ogawa, Wataru, Kasuga, Masato, Ghosh, Sankar
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768497/
https://www.ncbi.nlm.nih.gov/pubmed/19122654
http://dx.doi.org/10.1038/ni.1687

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