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Polymorphisms of the ICAM-1 exon 6 (E469K) are associated with differentiation of colorectal cancer

BACKGROUND: Genetic factors are thought to play a role in development for colorectal carcinogenesis. ICAM-1 is a polymorphic gene, thus, the present study investigated the relationship between the polymorphisms of ICAM-1 and the susceptibility and phenotypical characteristics of colorectal cancer (C...

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Autores principales: Wang, Qing-lei, Li, Bing-hui, Liu, Bin, Liu, Ya-bin, Liu, Yue-Ping, Miao, Sui-Bing, Han, Yi, Wen, Jin-Kun, Han, Mei
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768696/
https://www.ncbi.nlm.nih.gov/pubmed/19822019
http://dx.doi.org/10.1186/1756-9966-28-139
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author Wang, Qing-lei
Li, Bing-hui
Liu, Bin
Liu, Ya-bin
Liu, Yue-Ping
Miao, Sui-Bing
Han, Yi
Wen, Jin-Kun
Han, Mei
author_facet Wang, Qing-lei
Li, Bing-hui
Liu, Bin
Liu, Ya-bin
Liu, Yue-Ping
Miao, Sui-Bing
Han, Yi
Wen, Jin-Kun
Han, Mei
author_sort Wang, Qing-lei
collection PubMed
description BACKGROUND: Genetic factors are thought to play a role in development for colorectal carcinogenesis. ICAM-1 is a polymorphic gene, thus, the present study investigated the relationship between the polymorphisms of ICAM-1 and the susceptibility and phenotypical characteristics of colorectal cancer (CRC). METHODS: The polymorphisms at ICAM-1 exon 4 (G241R) and exon 6 (E469K) were detected by PCR with sequence-specific primers. The relationship between specific genotypes of ICAM-1 and differentiation of CRC was evaluated by the histological grade. RESULTS: We showed only GG genotype of ICAM-1 individuals in either CRC or normal controls. The KK genotype of ICAM-1 K469E was found more frequently than in the controls (P < 0.05). Patients with well-differentiated CRC displayed the KK more frequently than those of poor differentiation (P < 0.05). CONCLUSION: The findings indicate that polymorphisms of G241R are rare in Chinese population and that KK genotype of ICAM-1 K469E is significantly associated with well differentiation of CRC.
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spelling pubmed-27686962009-10-28 Polymorphisms of the ICAM-1 exon 6 (E469K) are associated with differentiation of colorectal cancer Wang, Qing-lei Li, Bing-hui Liu, Bin Liu, Ya-bin Liu, Yue-Ping Miao, Sui-Bing Han, Yi Wen, Jin-Kun Han, Mei J Exp Clin Cancer Res Research BACKGROUND: Genetic factors are thought to play a role in development for colorectal carcinogenesis. ICAM-1 is a polymorphic gene, thus, the present study investigated the relationship between the polymorphisms of ICAM-1 and the susceptibility and phenotypical characteristics of colorectal cancer (CRC). METHODS: The polymorphisms at ICAM-1 exon 4 (G241R) and exon 6 (E469K) were detected by PCR with sequence-specific primers. The relationship between specific genotypes of ICAM-1 and differentiation of CRC was evaluated by the histological grade. RESULTS: We showed only GG genotype of ICAM-1 individuals in either CRC or normal controls. The KK genotype of ICAM-1 K469E was found more frequently than in the controls (P < 0.05). Patients with well-differentiated CRC displayed the KK more frequently than those of poor differentiation (P < 0.05). CONCLUSION: The findings indicate that polymorphisms of G241R are rare in Chinese population and that KK genotype of ICAM-1 K469E is significantly associated with well differentiation of CRC. BioMed Central 2009-10-13 /pmc/articles/PMC2768696/ /pubmed/19822019 http://dx.doi.org/10.1186/1756-9966-28-139 Text en Copyright © 2009 Wang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Wang, Qing-lei
Li, Bing-hui
Liu, Bin
Liu, Ya-bin
Liu, Yue-Ping
Miao, Sui-Bing
Han, Yi
Wen, Jin-Kun
Han, Mei
Polymorphisms of the ICAM-1 exon 6 (E469K) are associated with differentiation of colorectal cancer
title Polymorphisms of the ICAM-1 exon 6 (E469K) are associated with differentiation of colorectal cancer
title_full Polymorphisms of the ICAM-1 exon 6 (E469K) are associated with differentiation of colorectal cancer
title_fullStr Polymorphisms of the ICAM-1 exon 6 (E469K) are associated with differentiation of colorectal cancer
title_full_unstemmed Polymorphisms of the ICAM-1 exon 6 (E469K) are associated with differentiation of colorectal cancer
title_short Polymorphisms of the ICAM-1 exon 6 (E469K) are associated with differentiation of colorectal cancer
title_sort polymorphisms of the icam-1 exon 6 (e469k) are associated with differentiation of colorectal cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768696/
https://www.ncbi.nlm.nih.gov/pubmed/19822019
http://dx.doi.org/10.1186/1756-9966-28-139
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