Strong association between pseudogenization mechanisms and gene sequence length

ABSTRACT: Pseudogenes arise from the decay of gene copies following either RNA-mediated duplication (processed pseudogenes) or DNA-mediated duplication (nonprocessed pseudogenes). Here, we show that long protein-coding genes tend to produce more nonprocessed pseudogenes than short genes, whereas the...

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Detalles Bibliográficos
Autores principales: Khachane, Amit N, Harrison, Paul M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Discovery Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768697/
https://www.ncbi.nlm.nih.gov/pubmed/19807910
http://dx.doi.org/10.1186/1745-6150-4-38
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author Khachane, Amit N
Harrison, Paul M
author_facet Khachane, Amit N
Harrison, Paul M
author_sort Khachane, Amit N
collection PubMed
description ABSTRACT: Pseudogenes arise from the decay of gene copies following either RNA-mediated duplication (processed pseudogenes) or DNA-mediated duplication (nonprocessed pseudogenes). Here, we show that long protein-coding genes tend to produce more nonprocessed pseudogenes than short genes, whereas the opposite is true for processed pseudogenes. Protein-coding genes longer than 3000 bp are 6 times more likely to produce nonprocessed pseudogenes than processed ones. REVIEWERS: This article was reviewed by Dr. Dan Graur and Dr. Craig Nelson (nominated by Dr. J Peter Gogarten).
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spelling pubmed-27686972009-10-28 Strong association between pseudogenization mechanisms and gene sequence length Khachane, Amit N Harrison, Paul M Biol Direct Discovery Notes ABSTRACT: Pseudogenes arise from the decay of gene copies following either RNA-mediated duplication (processed pseudogenes) or DNA-mediated duplication (nonprocessed pseudogenes). Here, we show that long protein-coding genes tend to produce more nonprocessed pseudogenes than short genes, whereas the opposite is true for processed pseudogenes. Protein-coding genes longer than 3000 bp are 6 times more likely to produce nonprocessed pseudogenes than processed ones. REVIEWERS: This article was reviewed by Dr. Dan Graur and Dr. Craig Nelson (nominated by Dr. J Peter Gogarten). BioMed Central 2009-10-06 /pmc/articles/PMC2768697/ /pubmed/19807910 http://dx.doi.org/10.1186/1745-6150-4-38 Text en Copyright © 2009 Khachane and Harrison; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Discovery Notes
Khachane, Amit N
Harrison, Paul M
Strong association between pseudogenization mechanisms and gene sequence length
title Strong association between pseudogenization mechanisms and gene sequence length
title_full Strong association between pseudogenization mechanisms and gene sequence length
title_fullStr Strong association between pseudogenization mechanisms and gene sequence length
title_full_unstemmed Strong association between pseudogenization mechanisms and gene sequence length
title_short Strong association between pseudogenization mechanisms and gene sequence length
title_sort strong association between pseudogenization mechanisms and gene sequence length
topic Discovery Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768697/
https://www.ncbi.nlm.nih.gov/pubmed/19807910
http://dx.doi.org/10.1186/1745-6150-4-38
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