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A Continuum of Cell States Spans Pluripotency and Lineage Commitment in Human Embryonic Stem Cells
BACKGROUND: Commitment in embryonic stem cells is often depicted as a binary choice between alternate cell states, pluripotency and specification to a particular germ layer or extraembryonic lineage. However, close examination of human ES cell cultures has revealed significant heterogeneity in the s...
Autores principales: | Hough, Shelley R., Laslett, Andrew L., Grimmond, Sean B., Kolle, Gabriel, Pera, Martin F. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768791/ https://www.ncbi.nlm.nih.gov/pubmed/19890402 http://dx.doi.org/10.1371/journal.pone.0007708 |
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