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Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes

Shiga-toxigenic Escherichia coli (STEC) use subtilase cytotoxin (SubAB) to interfere with adaptive immunity. Its inhibition of immunoglobulin secretion is both rapid and profound. SubAB favors cleavage of the newly synthesized immunoglobulin heavy chain–binding protein (BiP) to yield a C-terminal fr...

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Detalles Bibliográficos
Autores principales:	Hu, Chih-Chi Andrew, Dougan, Stephanie K., Winter, Sebastian Virreira, Paton, Adrienne W., Paton, James C., Ploegh, Hidde L.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768844/ https://www.ncbi.nlm.nih.gov/pubmed/19808260 http://dx.doi.org/10.1084/jem.20090782

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