Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

In normal T cell progenitors, phosphoinositide-dependent kinase l (PDK1)–mediated phosphorylation and activation of protein kinase B (PKB) is essential for the phosphorylation and inactivation of Foxo family transcription factors, and also controls T cell growth and proliferation. The current study...

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Detalles Bibliográficos
Autores principales: Finlay, David K., Sinclair, Linda V., Feijoo, Carmen, Waugh, Caryll M., Hagenbeek, Thijs J., Spits, Hergen, Cantrell, Doreen A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768858/
https://www.ncbi.nlm.nih.gov/pubmed/19808258
http://dx.doi.org/10.1084/jem.20090219

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