Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells

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Diffuse large B cell lymphoma (DLBCL) is the most common type of lymphoma in humans. The aggressive activated B cell–like (ABC) subtype of DLBCL is characterized by constitutive NF-κB activity and requires signals from CARD11, BCL10, and the paracaspase MALT1 for survival. CARD11, BCL10, and MALT1 a...

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Detalles Bibliográficos
Autores principales: Ferch, Uta, Kloo, Bernhard, Gewies, Andreas, Pfänder, Vera, Düwel, Michael, Peschel, Christian, Krappmann, Daniel, Ruland, Jürgen
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768866/
https://www.ncbi.nlm.nih.gov/pubmed/19841089
http://dx.doi.org/10.1084/jem.20091167
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