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Whole Genome Association Study in a Homogenous Population in Shandong Peninsula of China Reveals JARID2 as a Susceptibility Gene for Schizophrenia

DNA pooling can provide an economic and efficient way to detect susceptibility loci to complex diseases. We carried out a genome screen with 400 microsatellite markers spaced at approximately 10 cm in two DNA pools consisting of 119 schizophrenia (SZ) patients and 119 controls recruited from a homog...

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Autores principales: Liu, Yang, Chen, Gang, Norton, Nadine, Liu, Wenmin, Zhu, Haining, Zhou, Peng, Luan, Meng, Yang, Shulin, Chen, Xing, Carroll, Liam, Williams, Nigel M., O'Donovan, Michael C., Kirov, George, Owen, Michael J.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768871/
https://www.ncbi.nlm.nih.gov/pubmed/19884986
http://dx.doi.org/10.1155/2009/536918
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author Liu, Yang
Chen, Gang
Norton, Nadine
Liu, Wenmin
Zhu, Haining
Zhou, Peng
Luan, Meng
Yang, Shulin
Chen, Xing
Carroll, Liam
Williams, Nigel M.
O'Donovan, Michael C.
Kirov, George
Owen, Michael J.
author_facet Liu, Yang
Chen, Gang
Norton, Nadine
Liu, Wenmin
Zhu, Haining
Zhou, Peng
Luan, Meng
Yang, Shulin
Chen, Xing
Carroll, Liam
Williams, Nigel M.
O'Donovan, Michael C.
Kirov, George
Owen, Michael J.
author_sort Liu, Yang
collection PubMed
description DNA pooling can provide an economic and efficient way to detect susceptibility loci to complex diseases. We carried out a genome screen with 400 microsatellite markers spaced at approximately 10 cm in two DNA pools consisting of 119 schizophrenia (SZ) patients and 119 controls recruited from a homogenous population in the Chang Le area of the Shandong peninsula of China. Association of D6S289, a dinucleotide repeat polymorphism in the JARID2 gene with SZ, was found and confirmed by individual genotyping (X(2) = 17.89; P = .047). In order to refine the signal, we genotyped 14 single nucleotide polymorphisms (SNPs) covering JARID2 and the neighboring gene, DNTBP1, in an extended sample of 309 cases and 309 controls from Shandong peninsula (including the samples from the pools). However, rs2235258 and rs9654600 in JARID2 showed association in allelic, genotypic and haplotypic tests with SZ patients from Chang Le area. This was not replicates in the extended sample, we conclude that JARID2 could be a susceptibility gene for SZ.
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spelling pubmed-27688712009-11-02 Whole Genome Association Study in a Homogenous Population in Shandong Peninsula of China Reveals JARID2 as a Susceptibility Gene for Schizophrenia Liu, Yang Chen, Gang Norton, Nadine Liu, Wenmin Zhu, Haining Zhou, Peng Luan, Meng Yang, Shulin Chen, Xing Carroll, Liam Williams, Nigel M. O'Donovan, Michael C. Kirov, George Owen, Michael J. J Biomed Biotechnol Research Article DNA pooling can provide an economic and efficient way to detect susceptibility loci to complex diseases. We carried out a genome screen with 400 microsatellite markers spaced at approximately 10 cm in two DNA pools consisting of 119 schizophrenia (SZ) patients and 119 controls recruited from a homogenous population in the Chang Le area of the Shandong peninsula of China. Association of D6S289, a dinucleotide repeat polymorphism in the JARID2 gene with SZ, was found and confirmed by individual genotyping (X(2) = 17.89; P = .047). In order to refine the signal, we genotyped 14 single nucleotide polymorphisms (SNPs) covering JARID2 and the neighboring gene, DNTBP1, in an extended sample of 309 cases and 309 controls from Shandong peninsula (including the samples from the pools). However, rs2235258 and rs9654600 in JARID2 showed association in allelic, genotypic and haplotypic tests with SZ patients from Chang Le area. This was not replicates in the extended sample, we conclude that JARID2 could be a susceptibility gene for SZ. Hindawi Publishing Corporation 2009 2009-10-27 /pmc/articles/PMC2768871/ /pubmed/19884986 http://dx.doi.org/10.1155/2009/536918 Text en Copyright © 2009 Yang Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Yang
Chen, Gang
Norton, Nadine
Liu, Wenmin
Zhu, Haining
Zhou, Peng
Luan, Meng
Yang, Shulin
Chen, Xing
Carroll, Liam
Williams, Nigel M.
O'Donovan, Michael C.
Kirov, George
Owen, Michael J.
Whole Genome Association Study in a Homogenous Population in Shandong Peninsula of China Reveals JARID2 as a Susceptibility Gene for Schizophrenia
title Whole Genome Association Study in a Homogenous Population in Shandong Peninsula of China Reveals JARID2 as a Susceptibility Gene for Schizophrenia
title_full Whole Genome Association Study in a Homogenous Population in Shandong Peninsula of China Reveals JARID2 as a Susceptibility Gene for Schizophrenia
title_fullStr Whole Genome Association Study in a Homogenous Population in Shandong Peninsula of China Reveals JARID2 as a Susceptibility Gene for Schizophrenia
title_full_unstemmed Whole Genome Association Study in a Homogenous Population in Shandong Peninsula of China Reveals JARID2 as a Susceptibility Gene for Schizophrenia
title_short Whole Genome Association Study in a Homogenous Population in Shandong Peninsula of China Reveals JARID2 as a Susceptibility Gene for Schizophrenia
title_sort whole genome association study in a homogenous population in shandong peninsula of china reveals jarid2 as a susceptibility gene for schizophrenia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768871/
https://www.ncbi.nlm.nih.gov/pubmed/19884986
http://dx.doi.org/10.1155/2009/536918
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