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Potent Inhibition of HIV-1 Replication by a Tat Mutant

Herein we describe a mutant of the two-exon HIV-1 Tat protein, termed Nullbasic, that potently inhibits multiple steps of the HIV-1 replication cycle. Nullbasic was created by replacing the entire arginine-rich basic domain of wild type Tat with glycine/alanine residues. Like similarly mutated one-e...

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Detalles Bibliográficos
Autores principales:	Meredith, Luke W., Sivakumaran, Haran, Major, Lee, Suhrbier, Andreas, Harrich, David
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768900/ https://www.ncbi.nlm.nih.gov/pubmed/19901984 http://dx.doi.org/10.1371/journal.pone.0007769

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