Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection

BACKGROUND: Nitrogen-containing bisphosphonates are the elected drugs for the treatment of diseases in which excessive bone resorption occurs, for example, osteoporosis and cancer-induced bone diseases. The only known target of nitrogen-containing bisphosphonates is farnesyl pyrophosphate synthase,...

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Detalles Bibliográficos
Autores principales: Bivi, Nicoletta, Romanello, Milena, Harrison, Richard, Clarke, Ian, Hoyle, David C, Moro, Luigi, Ortolani, Fulvia, Bonetti, Antonella, Quadrifoglio, Franco, Tell, Gianluca, Delneri, Daniela
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768982/
https://www.ncbi.nlm.nih.gov/pubmed/19744312
http://dx.doi.org/10.1186/gb-2009-10-9-r93

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