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Adenosine Neuromodulation and Traumatic Brain Injury
Adenosine is a ubiquitous signaling molecule, with widespread activity across all organ systems. There is evidence that adenosine regulation is a significant factor in traumatic brain injury (TBI) onset, recovery, and outcome, and a growing body of experimental work examining the therapeutic potenti...
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Formato: | Texto |
Lenguaje: | English |
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Bentham Science Publishers Ltd.
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769006/ https://www.ncbi.nlm.nih.gov/pubmed/20190964 http://dx.doi.org/10.2174/157015909789152137 |
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author | Lusardi, T.A |
author_facet | Lusardi, T.A |
author_sort | Lusardi, T.A |
collection | PubMed |
description | Adenosine is a ubiquitous signaling molecule, with widespread activity across all organ systems. There is evidence that adenosine regulation is a significant factor in traumatic brain injury (TBI) onset, recovery, and outcome, and a growing body of experimental work examining the therapeutic potential of adenosine neuromodulation in the treatment of TBI. In the central nervous system (CNS), adenosine (dys)regulation has been demonstrated following TBI, and correlated to several TBI pathologies, including impaired cerebral hemodynamics, anaerobic metabolism, and inflammation. In addition to acute pathologies, adenosine function has been implicated in TBI comorbidities, such as cognitive deficits, psychiatric function, and post-traumatic epilepsy. This review presents studies in TBI as well as adenosine-related mechanisms in co-morbidities of and unfavorable outcomes resulting from TBI. While the exact role of the adenosine system following TBI remains unclear, there is increasing evidence that a thorough understanding of adenosine signaling will be critical to the development of diagnostic and therapeutic tools for the treatment of TBI. |
format | Text |
id | pubmed-2769006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Bentham Science Publishers Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-27690062010-03-01 Adenosine Neuromodulation and Traumatic Brain Injury Lusardi, T.A Curr Neuropharmacol Article Adenosine is a ubiquitous signaling molecule, with widespread activity across all organ systems. There is evidence that adenosine regulation is a significant factor in traumatic brain injury (TBI) onset, recovery, and outcome, and a growing body of experimental work examining the therapeutic potential of adenosine neuromodulation in the treatment of TBI. In the central nervous system (CNS), adenosine (dys)regulation has been demonstrated following TBI, and correlated to several TBI pathologies, including impaired cerebral hemodynamics, anaerobic metabolism, and inflammation. In addition to acute pathologies, adenosine function has been implicated in TBI comorbidities, such as cognitive deficits, psychiatric function, and post-traumatic epilepsy. This review presents studies in TBI as well as adenosine-related mechanisms in co-morbidities of and unfavorable outcomes resulting from TBI. While the exact role of the adenosine system following TBI remains unclear, there is increasing evidence that a thorough understanding of adenosine signaling will be critical to the development of diagnostic and therapeutic tools for the treatment of TBI. Bentham Science Publishers Ltd. 2009-09 /pmc/articles/PMC2769006/ /pubmed/20190964 http://dx.doi.org/10.2174/157015909789152137 Text en ©2009 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Lusardi, T.A Adenosine Neuromodulation and Traumatic Brain Injury |
title | Adenosine Neuromodulation and Traumatic Brain Injury |
title_full | Adenosine Neuromodulation and Traumatic Brain Injury |
title_fullStr | Adenosine Neuromodulation and Traumatic Brain Injury |
title_full_unstemmed | Adenosine Neuromodulation and Traumatic Brain Injury |
title_short | Adenosine Neuromodulation and Traumatic Brain Injury |
title_sort | adenosine neuromodulation and traumatic brain injury |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769006/ https://www.ncbi.nlm.nih.gov/pubmed/20190964 http://dx.doi.org/10.2174/157015909789152137 |
work_keys_str_mv | AT lusardita adenosineneuromodulationandtraumaticbraininjury |