Extramedullary relapse of IgA-lambda myeloma after recent bortezomib therapy: a case report

Intracranial plasmacytomas are an uncommon presentation of extramedullary relapse of multiple myeloma. The optimal management of extramedullary plasmacytomas remains unclear, with initial reports of bortezomib showing promising clinical results. We describe a case of multiple extracellular, includin...

Descripción completa

Detalles Bibliográficos
Autores principales: Waterhouse, Deirdre F, Moloney, Geraldine A, Gargoum, Fatma S, Hayden, Peter S, O’Gorman, Tom
Formato: Texto
Lenguaje:English
Publicado: Cases Network Ltd 2009
Materias:
Case report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769356/
https://www.ncbi.nlm.nih.gov/pubmed/19918466
http://dx.doi.org/10.4076/1757-1626-2-7456
_version_ 1782173578948509696
author Waterhouse, Deirdre F
Moloney, Geraldine A
Gargoum, Fatma S
Hayden, Peter S
O’Gorman, Tom
author_facet Waterhouse, Deirdre F
Moloney, Geraldine A
Gargoum, Fatma S
Hayden, Peter S
O’Gorman, Tom
author_sort Waterhouse, Deirdre F
collection PubMed
description Intracranial plasmacytomas are an uncommon presentation of extramedullary relapse of multiple myeloma. The optimal management of extramedullary plasmacytomas remains unclear, with initial reports of bortezomib showing promising clinical results. We describe a case of multiple extracellular, including intracranial, plasmacytoma, with no evidence of marrow involvement, in a patient with relapsed IgA multiple myeloma. To our knowledge, this is the first reported case of a patient with rapid extramedullary relapse of disease despite recent exposure to bortezomib and dexamethasone.
format Text
id pubmed-2769356
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Cases Network Ltd
record_format MEDLINE/PubMed
spelling pubmed-27693562009-11-16 Extramedullary relapse of IgA-lambda myeloma after recent bortezomib therapy: a case report Waterhouse, Deirdre F Moloney, Geraldine A Gargoum, Fatma S Hayden, Peter S O’Gorman, Tom Cases J Case report Intracranial plasmacytomas are an uncommon presentation of extramedullary relapse of multiple myeloma. The optimal management of extramedullary plasmacytomas remains unclear, with initial reports of bortezomib showing promising clinical results. We describe a case of multiple extracellular, including intracranial, plasmacytoma, with no evidence of marrow involvement, in a patient with relapsed IgA multiple myeloma. To our knowledge, this is the first reported case of a patient with rapid extramedullary relapse of disease despite recent exposure to bortezomib and dexamethasone. Cases Network Ltd 2009-09-14 /pmc/articles/PMC2769356/ /pubmed/19918466 http://dx.doi.org/10.4076/1757-1626-2-7456 Text en © 2009 Waterhouse et al.; licensee Cases Network Ltd. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case report
Waterhouse, Deirdre F
Moloney, Geraldine A
Gargoum, Fatma S
Hayden, Peter S
O’Gorman, Tom
Extramedullary relapse of IgA-lambda myeloma after recent bortezomib therapy: a case report
title Extramedullary relapse of IgA-lambda myeloma after recent bortezomib therapy: a case report
title_full Extramedullary relapse of IgA-lambda myeloma after recent bortezomib therapy: a case report
title_fullStr Extramedullary relapse of IgA-lambda myeloma after recent bortezomib therapy: a case report
title_full_unstemmed Extramedullary relapse of IgA-lambda myeloma after recent bortezomib therapy: a case report
title_short Extramedullary relapse of IgA-lambda myeloma after recent bortezomib therapy: a case report
title_sort extramedullary relapse of iga-lambda myeloma after recent bortezomib therapy: a case report
topic Case report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769356/
https://www.ncbi.nlm.nih.gov/pubmed/19918466
http://dx.doi.org/10.4076/1757-1626-2-7456
work_keys_str_mv AT waterhousedeirdref extramedullaryrelapseofigalambdamyelomaafterrecentbortezomibtherapyacasereport
AT moloneygeraldinea extramedullaryrelapseofigalambdamyelomaafterrecentbortezomibtherapyacasereport
AT gargoumfatmas extramedullaryrelapseofigalambdamyelomaafterrecentbortezomibtherapyacasereport
AT haydenpeters extramedullaryrelapseofigalambdamyelomaafterrecentbortezomibtherapyacasereport
AT ogormantom extramedullaryrelapseofigalambdamyelomaafterrecentbortezomibtherapyacasereport

Ejemplares similares