Bilateral injection-site granuloma by subcutaneous administration of luteinizing hormone-releasing hormone analogue: a case report

We report a typical case of injection-site granuloma attributed to subcutaneous administration of leuprorelin acetate, an LHRH agonist. A 70-year-old man who had undergone total prostatectomy and was subsequently given leuprorelin injections for prostatic cancer presented with bilateral nodules in t...

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Autores principales: Kitazawa, Riko, Yamamichi, Fukashi, Hidaka, Toshiharu, Morishita, Shinichi, Kondo, Takeshi, Mori, Kiyoshi, Kitazawa, Sohei
Formato: Texto
Lenguaje:English
Publicado: Cases Network Ltd 2009
Materias:
Case report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769429/
https://www.ncbi.nlm.nih.gov/pubmed/19918419
http://dx.doi.org/10.4076/1757-1626-2-8326
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author Kitazawa, Riko
Yamamichi, Fukashi
Hidaka, Toshiharu
Morishita, Shinichi
Kondo, Takeshi
Mori, Kiyoshi
Kitazawa, Sohei
author_facet Kitazawa, Riko
Yamamichi, Fukashi
Hidaka, Toshiharu
Morishita, Shinichi
Kondo, Takeshi
Mori, Kiyoshi
Kitazawa, Sohei
author_sort Kitazawa, Riko
collection PubMed
description We report a typical case of injection-site granuloma attributed to subcutaneous administration of leuprorelin acetate, an LHRH agonist. A 70-year-old man who had undergone total prostatectomy and was subsequently given leuprorelin injections for prostatic cancer presented with bilateral nodules in the lower abdominal wall. An excisional biopsy revealed a non-caseous epithelioid granuloma consisting of CD-68 positive histiocytic cells with infiltration of T-lymphocytes and eosinophils; skin metastasis from prostatic adenocarcinoma was ruled out through histological and immunohistochemical analysis. Generally, granulomas may be caused by delayed-type hypersensitivity to the constituents of leuprorelin acetate injections.
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spelling pubmed-27694292009-11-16 Bilateral injection-site granuloma by subcutaneous administration of luteinizing hormone-releasing hormone analogue: a case report Kitazawa, Riko Yamamichi, Fukashi Hidaka, Toshiharu Morishita, Shinichi Kondo, Takeshi Mori, Kiyoshi Kitazawa, Sohei Cases J Case report We report a typical case of injection-site granuloma attributed to subcutaneous administration of leuprorelin acetate, an LHRH agonist. A 70-year-old man who had undergone total prostatectomy and was subsequently given leuprorelin injections for prostatic cancer presented with bilateral nodules in the lower abdominal wall. An excisional biopsy revealed a non-caseous epithelioid granuloma consisting of CD-68 positive histiocytic cells with infiltration of T-lymphocytes and eosinophils; skin metastasis from prostatic adenocarcinoma was ruled out through histological and immunohistochemical analysis. Generally, granulomas may be caused by delayed-type hypersensitivity to the constituents of leuprorelin acetate injections. Cases Network Ltd 2009-09-15 /pmc/articles/PMC2769429/ /pubmed/19918419 http://dx.doi.org/10.4076/1757-1626-2-8326 Text en © 2009 Kitazawa et al.; licensee Cases Network Ltd. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case report
Kitazawa, Riko
Yamamichi, Fukashi
Hidaka, Toshiharu
Morishita, Shinichi
Kondo, Takeshi
Mori, Kiyoshi
Kitazawa, Sohei
Bilateral injection-site granuloma by subcutaneous administration of luteinizing hormone-releasing hormone analogue: a case report
title Bilateral injection-site granuloma by subcutaneous administration of luteinizing hormone-releasing hormone analogue: a case report
title_full Bilateral injection-site granuloma by subcutaneous administration of luteinizing hormone-releasing hormone analogue: a case report
title_fullStr Bilateral injection-site granuloma by subcutaneous administration of luteinizing hormone-releasing hormone analogue: a case report
title_full_unstemmed Bilateral injection-site granuloma by subcutaneous administration of luteinizing hormone-releasing hormone analogue: a case report
title_short Bilateral injection-site granuloma by subcutaneous administration of luteinizing hormone-releasing hormone analogue: a case report
title_sort bilateral injection-site granuloma by subcutaneous administration of luteinizing hormone-releasing hormone analogue: a case report
topic Case report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769429/
https://www.ncbi.nlm.nih.gov/pubmed/19918419
http://dx.doi.org/10.4076/1757-1626-2-8326
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