Sign of Leser-Trélat with an adenocarcinoma of the prostate: a case report

INTRODUCTION: The sign of Leser-Trélat is defined by the sudden appearance and rapid increase in number and size of seborrheic keratoses, preceding or revealing a malignancy. Even though this sign remains controversial, it has been described during a wide range of malignancies, including mainly adenocarcinoma of the gastro-intestinal tract or the breast. CASE PRESENTATION: We report the case of a 68-year-old man who experienced sudden increased in number of seborrheic keratoses within two years prior to a diagnosis of adenocarcinoma of the prostate. After prostatectomy, pigmented lesions stopped their brutal increase but did not regress. CONCLUSION: This is the second case of adenocarcinoma of the prostate associated with the sign of Leser-Trélat. This report acts as a reminder that in case of Leser-Trélat sign, a complete physical examination is mandatory followed by specific complementary exams.